Defeating Drug Resistance in Cancer

Overview

Journal Discov Med

Specialty General Medicine

Date 2007 Jan 20

PMID 17234123

Citations 27

Authors

Michael M Gottesman

Joseph Ludwig

Di Xia

Gergely Szakacs

Affiliations

Soon will be listed here.

Abstract

Multiple resistance to cytotoxic cancer drugs dramatically reduces the effectiveness of these drugs on many occasions. ABC (ATP-binding cassette) transporters pump out cytotoxic cancer drugs from cells, preventing them from reaching therapeutic levels. However, co-administration ABC transporter inhibitors with cytotoxic cancer drugs did not effectively improve the treatment outcome. The mechanisms and remedies are discussed.

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