Targeting of the Sendai Virus C Protein to the Plasma Membrane Via a Peptide-only Membrane Anchor

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2007 Jan 19

PMID 17229713

Citations 13

Authors

Jean-Baptiste Marq

Albert Brini

Daniel Kolakofsky

Dominique Garcin

Affiliations

Soon will be listed here.

Abstract

Several cellular proteins are synthesized in the cytosol on free ribosomes and then associate with membranes due to the presence of short peptide sequences. These membrane-targeting sequences contain sites to which lipid chains are attached, which help direct the protein to a particular membrane domain and anchor it firmly in the bilayer. The intracellular concentration of these proteins in particular cellular compartments, where their interacting partners are also concentrated, is essential to their function. This paper reports that the apparently unmodified N-terminal sequence of the Sendai virus C protein (MPSFLKKILKLRGRR . . .; letters in italics represent hydrophobic residues; underlined letters represent basic residues, which has a strong propensity to form an amphipathic alpha-helix in a hydrophobic environment) also function as a membrane targeting signal and membrane anchor. Moreover, the intracellular localization of the C protein at the plasma membrane is essential for inducing the interferon-independent phosphorylation of Stat1 as part of the viral program to prevent the cellular antiviral response.

Citing Articles

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Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding.

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Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade of type 1 interferon signaling.

Oda K, Oda T, Matoba Y, Sato M, Irie T, Sakaguchi T J Biol Chem. 2017; 292(48):19752-19766.

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Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III.

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Evolution and structural organization of the C proteins of paramyxovirinae.

Lo M, Sogaard T, Karlin D PLoS One. 2014; 9(2):e90003.

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