Prediction of Aortic Peak Enhancement in Monophasic Contrast Injection Protocols at Multidetector CT: Phantom and Patient Studies

Overview

Journal Radiat Med

Specialties Nuclear Medicine
Oncology
Radiology

Date 2007 Jan 17

PMID 17225048

Citations 5

Authors

Kazuo Awai

Yoshiharu Nakayama

Takeshi Nakaura

Yumi Yanaga

Yoshitaka Tamura

Masahiro Hatemura

Yoshinori Funama

Yasuyuki Yamashita

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim of this study was to investigate whether it is possible to predict aortic peak enhancement (APE) from the contrast dose and injection rate.

Materials And Methods: We first undertook an experimental study using a flow phantom that simulates the human circulation. We delivered 90-150 ml of iomeprol-350 at various injection rates and measured the APE values of the simulated aorta. In our clinical study we randomized 20 patients into four groups. In groups A, B, and C the iodine dose per kilogram of body weight (BW) ranged from 450 to 600 mg, and the injection duration was fixed at 30 s; group D received 450 mg/kg over 25 s. We then measured APE in all patients at the whole aorta, averaged the three highest values, and took the result as APE.

Results: In the phantom study, the decision coefficient for the best-fit equation obtained by multiple regression analysis of the relation between the iodine dose and injection rate and the simulated APE was high (0.93). In the patient study, the predicted APE values almost corresponded with the averaged APE values when we applied the fitness equation.

Conclusion: Using our fitness equation, APE on contrast-enhanced computed tomography can be predicted from the iodine dose and the contrast injection rate per patient weight.

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