Pneumolysin, PspA, and PspC Contribute to Pneumococcal Evasion of Early Innate Immune Responses During Bacteremia in Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2007 Jan 16

PMID 17220305

Citations 36

Authors

Lisa R Quin

Quincy C Moore 3rd

Larry S McDaniel

Affiliations

Soon will be listed here.

Abstract

The pneumococcal virulence factors include capsule, PspA, PspC, and Ply. Cytometric analysis demonstrated that the greatest levels of C3 deposition were on a Deltaply PspA(-) PspC(-) mutant. Also, Ply, PspA, and PspC expression resulted in C3 degradation in vitro and in vivo. Finally, blood clearance assays demonstrated that there was enhanced clearance of Deltaply PspA(-) PspC(-) pneumococci compared to the clearance of nonencapsulated pneumococci.

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