Sex Steroids and Potential Mechanisms of Non-genomic Endocrine Disruption in Invertebrates

Overview

Journal Ecotoxicology

Specialties Environmental Health
Toxicology

Date 2007 Jan 16

PMID 17219086

Citations 28

Authors

Gemma Janer

Cinta Porte

Affiliations

Soon will be listed here.

Abstract

The review reports on the presence and metabolism of sex steroids in several invertebrate species and provides detailed information on possible mechanisms of endocrine disruption other than the interaction with nuclear receptors. The presence of most vertebrate sex steroids in invertebrate tissues has been demonstrated by liquid or gas chromatography coupled to mass spectrometry. In addition, enzymatic pathways involved in the steroidogenic pathway have been described in at least some invertebrate phyla. Some endocrine disruptors induce alterations in these metabolic pathways and might lead to changes in steroid levels. Growing evidence suggests that estradiol can act through non-genomic pathways in molluscs, and that xenobiotics can as well interfere in these signalling cascades. In spite of these recent advances, most question marks on the action and function of sex steroids in invertebrates remain to be answered.

Citing Articles

Sex reversal induced by 17β-estradiol may be achieved by regulating the neuroendocrine system of the Pacific white shrimp Penaeus vannamei.

Wang T, Li S, Yu Y, Li F BMC Genomics. 2025; 26(1):86.

PMID: 39881223 PMC: 11776206. DOI: 10.1186/s12864-025-11236-2.

A new type II CHH neuropeptide involves ovarian development in the peppermint shrimp, Lysmata vittata.

Lan H, Liu F, Lu L, Liu A, Ye H PLoS One. 2024; 19(8):e0305127.

PMID: 39088423 PMC: 11293640. DOI: 10.1371/journal.pone.0305127.

Insights on the Organ-Dependent, Molecular Sexual Dimorphism in the Zebra Mussel, , Revealed by Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Metabolomics.

Lance E, Sartor L, Foucault P, Geffard A, Marie B Metabolites. 2023; 13(10).

PMID: 37887371 PMC: 10609167. DOI: 10.3390/metabo13101046.

A Novel Estrogen Related Receptor (RmERR), a Molecular and In Silico Characterization of a Potential Protein Binding Estrogen.

Aguilar-Diaz H, Quiroz-Castaneda R, Diaz-Esquivel I, Cossio-Bayugar R, Miranda-Miranda E Microorganisms. 2023; 11(9).

PMID: 37764138 PMC: 10536290. DOI: 10.3390/microorganisms11092294.

Function and regulation of a steroidogenic CYP450 enzyme in the mitochondrion of Toxoplasma gondii.

Asady B, Sampels V, Romano J, Levitskaya J, Lige B, Khare P PLoS Pathog. 2023; 19(8):e1011566.

PMID: 37651449 PMC: 10499268. DOI: 10.1371/journal.ppat.1011566.

References

Gooding M, Leblanc G . Biotransformation and disposition of testosterone in the eastern mud snail Ilyanassa obsoleta. Gen Comp Endocrinol. 2001; 122(2):172-80. DOI: 10.1006/gcen.2001.7630. View

Lavado R, Barbaglio A, Candia Carnevali M, Porte C . Steroid levels in crinoid echinoderms are altered by exposure to model endocrine disruptors. Steroids. 2006; 71(6):489-97. DOI: 10.1016/j.steroids.2006.01.009. View

Janer G, Sternberg R, Leblanc G, Porte C . Testosterone conjugating activities in invertebrates: are they targets for endocrine disruptors?. Aquat Toxicol. 2005; 71(3):273-82. DOI: 10.1016/j.aquatox.2004.11.024. View

Wasson K, Watts S . Progesterone metabolism in the ovaries and testes of the echinoid Lytechinus variegatus Lamarck (Echinodermata). Comp Biochem Physiol C Toxicol Pharmacol. 2001; 127(3):263-72. DOI: 10.1016/s0742-8413(00)00153-5. View

Voogt P, den Besten P, Kusters G, Messing M . Effects of cadmium and zinc on steroid metabolism and steroid level in the sea star Asterias rubens L. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987; 86(1):83-9. DOI: 10.1016/0742-8413(87)90148-4. View

Hochberg R . Biological esterification of steroids. Endocr Rev. 1998; 19(3):331-48. DOI: 10.1210/edrv.19.3.0330. View

Wilson J . The role of 5alpha-reduction in steroid hormone physiology. Reprod Fertil Dev. 2002; 13(7-8):673-8. DOI: 10.1071/rd01074. View

Baker M . Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action. Mol Cell Endocrinol. 2001; 171(1-2):211-5. DOI: 10.1016/s0303-7207(00)00414-7. View

Thibaut R, Porte C . Effects of endocrine disrupters on sex steroid synthesis and metabolism pathways in fish. J Steroid Biochem Mol Biol. 2005; 92(5):485-94. DOI: 10.1016/j.jsbmb.2004.10.008. View

10.

Dutton G . Uridine diphosphate glucose and the synthesis of phenolic glucosides by mollusks. Arch Biochem Biophys. 1966; 116(1):399-405. DOI: 10.1016/0003-9861(66)90046-4. View

11.

Gooding M, Wilson V, Folmar L, Marcovich D, LeBlanc G . The biocide tributyltin reduces the accumulation of testosterone as fatty acid esters in the mud snail (Ilyanassa obsoleta). Environ Health Perspect. 2003; 111(4):426-30. PMC: 1241423. DOI: 10.1289/ehp.5779. View

12.

Zhu W, Mantione K, Jones D, Salamon E, Cho J, Cadet P . The presence of 17-beta estradiol in Mytilus edulis gonadal tissues: evidence for estradiol isoforms. Neuro Endocrinol Lett. 2003; 24(3-4):137-40. View

13.

Janer G, Leblanc G, Porte C . A comparative study on androgen metabolism in three invertebrate species. Gen Comp Endocrinol. 2005; 143(3):211-21. DOI: 10.1016/j.ygcen.2005.03.016. View

14.

Lavado R, Janer G, Porte C . Steroid levels and steroid metabolism in the mussel Mytilus edulis: the modulating effect of dispersed crude oil and alkylphenols. Aquat Toxicol. 2006; 78 Suppl 1:S65-72. DOI: 10.1016/j.aquatox.2006.02.018. View

15.

Morcillo Y, Porte C . Evidence of endocrine disruption in the imposex-affected gastropod Bolinus brandaris. Environ Res. 1999; 81(4):349-54. DOI: 10.1006/enrs.1999.4002. View

16.

Canesi L, Lorusso L, Ciacci C, Betti M, Zampini M, Gallo G . Environmental estrogens can affect the function of mussel hemocytes through rapid modulation of kinase pathways. Gen Comp Endocrinol. 2004; 138(1):58-69. DOI: 10.1016/j.ygcen.2004.05.004. View

17.

Stroomberg G, Zappey H, Steen R, van Gestel C, Ariese F, Velthorst N . PAH biotransformation in terrestrial invertebrates--a new phase II metabolite in isopods and springtails. Comp Biochem Physiol C Toxicol Pharmacol. 2004; 138(2):129-37. DOI: 10.1016/j.cca.2004.06.004. View

18.

Wasson K, Hines G, Watts S . Synthesis of testosterone and 5alpha-androstanediols during nutritionally stimulated gonadal growth in Lytechinus variegatus lamarck (Echinodermata:Echinoidea). Gen Comp Endocrinol. 1998; 111(2):197-206. DOI: 10.1006/gcen.1998.7105. View

19.

James M, Boyle S . Cytochromes P450 in crustacea. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999; 121(1-3):157-72. DOI: 10.1016/s0742-8413(98)10036-1. View

20.

Slinger A, Isaac R . Synthesis of apolar ecdysone esters by ovaries of the cockroach Periplaneta americana. Gen Comp Endocrinol. 1988; 70(1):74-82. DOI: 10.1016/0016-6480(88)90095-0. View