The Unfolded Protein Response and Cancer: a Brighter Future Unfolding?

Overview

Journal J Mol Med (Berl)

Specialty General Medicine

Date 2007 Jan 12

PMID 17216204

Citations 33

Authors

Peter Scriven

Nicola J Brown

A Graham Pockley

Lynda Wyld

Affiliations

Soon will be listed here.

Abstract

Mammalian cells are bathed in an interstitial fluid that has a tightly regulated composition in healthy states. Interstitial fluid provides cells with all the necessary metabolic substrates (oxygen, glucose, amino acids, etc.), and waste molecules are removed by diffusion gradients that are controlled by local vascular perfusion. The health and normal function of all cells within a body is dependent on the maintenance of this microenvironment. However, many disease states cause fluctuations in this, and in some instances, these might be of sufficient severity to stress and/or be toxic to the cell. Cells have developed a number of responses to enable their survival in a hostile environment. This article discusses one such pathway--the unfolded protein response and its relationship to cancer. The molecular signalling cascade, the mechanism of its activation in cancer and the consequences of its activation for a tumour are discussed, as are clinical studies and potential translational approaches for utilising this pathway for tumour targeting.

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