Neuroprotection Against Surgically Induced Brain Injury

Overview

Journal Surg Neurol

Specialty Neurosurgery

Date 2007 Jan 11

PMID 17210286

Citations 32

Authors

Vikram Jadhav

Ihsan Solaroglu

Andre Obenaus

John H Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Neurosurgical procedures are carried out routinely in health institutions across the world. A key issue to be considered during neurosurgical interventions is that there is always an element of inevitable brain injury that results from the procedure itself because of the unique nature of the nervous system. Brain tissue at the periphery of the operative site is at risk of injury by various means, including incisions and direct trauma, electrocautery, hemorrhage, and retractor stretch.

Methods/results: In the present review, we will elaborate upon this surgically induced brain injury and also present a novel animal model to study it. In addition, we will summarize preliminary results obtained by pretreatment with PP1, an Src tyrosine kinase inhibitor reported to have neuroprotective properties in in vivo experimental studies. Any form of pretreatment to limit the damage to the susceptible functional brain tissue during neurosurgical procedures may have a significant impact on patient recovery.

Conclusion: This brief review is intended to raise the question of 'neuroprotection against surgically induced brain injury' in the neurosurgical scientific community and stimulate discussions.

Citing Articles

General Treatments Promoting Independent Living in Parkinson's Patients and Physical Therapy Approaches for Improving Gait-A Comprehensive Review.

Lee D, Woo B, Park Y, Lee J Medicina (Kaunas). 2024; 60(5).

PMID: 38792894 PMC: 11123276. DOI: 10.3390/medicina60050711.

Intracerebellar injection of monocytic immature myeloid cells prevents the adverse effects caused by stereotactic surgery in a model of cerebellar neurodegeneration.

Del Pilar C, Garrido-Matilla L, Del Pozo-Filiu L, Lebron-Galan R, Arias R, Clemente D J Neuroinflammation. 2024; 21(1):49.

PMID: 38355633 PMC: 10867997. DOI: 10.1186/s12974-023-03000-8.

Multimodal Intraoperative Neurophysiological Monitoring in Cranial and Spinal Tumour Surgeries: A Descriptive Observational Study.

Gupta S, Siddiqui S, Sinha U, Gupta G Cureus. 2023; 15(11):e49411.

PMID: 38149147 PMC: 10750011. DOI: 10.7759/cureus.49411.

Cerebrospinal Fluid from Patients After Craniotomy with the Appearance of Interleukin-6 Storm Can Activate Microglia to Damage the Hypothalamic Neurons in Mice.

Huang H, Liao X, Zhang A, Qiu B, Mei F, Liu F Mol Neurobiol. 2023; 61(5):2707-2718.

PMID: 37924484 DOI: 10.1007/s12035-023-03693-1.

Effects of Dimethyl Fumarate on the Karnofsky Performance Status and Serum S100β Level in Newly Glioblastoma Patients: A Randomized, Phase-II, Placebo, Triple Blinded, Controlled Trial: Effect of DMF On the Serum S100β Level and KPS Score of GBM....

Milad S, Ehsan J, Seyed Farzad M, Mohsen R, Ahmad B, Shahram M Galen Med J. 2022; 10:1-10.

PMID: 36340958 PMC: 9616682. DOI: 10.31661/gmj.v11i.1897.

References

Xi G, Hua Y, Keep R, Younger J, Hoff J . Brain edema after intracerebral hemorrhage: the effects of systemic complement depletion. Acta Neurochir Suppl. 2002; 81:253-6. DOI: 10.1007/978-3-7091-6738-0_66. View

Mori T, Wang X, Aoki T, Lo E . Downregulation of matrix metalloproteinase-9 and attenuation of edema via inhibition of ERK mitogen activated protein kinase in traumatic brain injury. J Neurotrauma. 2002; 19(11):1411-9. DOI: 10.1089/089771502320914642. View

Freudenstein D, Wagner A, Ernemann U, Duffner F . Subdural hygroma as a complication of endoscopic neurosurgery--two case reports. Neurol Med Chir (Tokyo). 2003; 42(12):554-9. DOI: 10.2176/nmc.42.554. View

Wang E, Yong N, Ng I . Endoscopic assisted microneurosurgery for cerebral aneurysms. J Clin Neurosci. 2003; 10(2):174-6. DOI: 10.1016/s0967-5868(02)00320-x. View

Kusaka G, Kimura H, Kusaka I, Perkins E, Nanda A, Zhang J . Contribution of Src tyrosine kinase to cerebral vasospasm after subarachnoid hemorrhage. J Neurosurg. 2003; 99(2):383-90. DOI: 10.3171/jns.2003.99.2.0383. View

Hellwig D, Bertalanffy H, Bauer B, Tirakotai W . Pontine hemorrhage. J Neurosurg. 2003; 99(4):796. DOI: 10.3171/jns.2003.99.4.0796. View

Solaroglu I, Beskonakli E, Kaptanoglu E, Okutan O, Ak F, Taskin Y . Transcortical-transventricular approach in colloid cysts of the third ventricle: surgical experience with 26 cases. Neurosurg Rev. 2003; 27(2):89-92. DOI: 10.1007/s10143-003-0309-2. View

Kusaka G, Calvert J, Smelley C, Nanda A, Zhang J . New lumbar method for monitoring cerebrospinal fluid pressure in rats. J Neurosci Methods. 2004; 135(1-2):121-7. DOI: 10.1016/j.jneumeth.2003.12.013. View

Blair R . The roles of orbital frontal cortex in the modulation of antisocial behavior. Brain Cogn. 2004; 55(1):198-208. DOI: 10.1016/S0278-2626(03)00276-8. View

10.

Kusaka G, Ishikawa M, Nanda A, Granger D, Zhang J . Signaling pathways for early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2004; 24(8):916-25. DOI: 10.1097/01.WCB.0000125886.48838.7E. View

11.

ROSSNER W, Tempel K . [Quantitative determination of the permeability of the so-called blood-brain barrier of Evans blue (T 1824)]. Med Pharmacol Exp Int J Exp Med. 1966; 14(2):169-82. View

12.

Glick S . Modulation of food and water intake by frontal cortex in the rat. Commun Behav Biol. 1971; 5(6):365-70. View

13.

Glick S, Greenstein S . Recovery of weight regulation following ablation of frontal cortex in rats. Physiol Behav. 1973; 10(3):491-6. DOI: 10.1016/0031-9384(73)90211-4. View

14.

de Bruin J, Van Oyen H, van de Poll N . Behavioural changes following lesions of the orbital prefrontal cortex in male rats. Behav Brain Res. 1983; 10(2-3):209-32. DOI: 10.1016/0166-4328(83)90032-3. View

15.

Uyama O, Okamura N, Yanase M, Narita M, Kawabata K, Sugita M . Quantitative evaluation of vascular permeability in the gerbil brain after transient ischemia using Evans blue fluorescence. J Cereb Blood Flow Metab. 1988; 8(2):282-4. DOI: 10.1038/jcbfm.1988.59. View

16.

Froeschner E . Two examples of ancient skull surgery. J Neurosurg. 1992; 76(3):550-2. DOI: 10.3171/jns.1992.76.3.0550. View

17.

Andrews R, Muto R . Retraction brain ischaemia: cerebral blood flow, evoked potentials, hypotension and hyperventilation in a new animal model. Neurol Res. 1992; 14(1):12-8. DOI: 10.1080/01616412.1992.11740004. View

18.

FASANO V, Penna G . [Postoperative complications in neurosurgery]. Minerva Anestesiol. 1992; 58(4 Suppl 1):15-21. View

19.

Tommasino C . [Postoperative cerebral edema. Physiopathology of the edema and medical therapy]. Minerva Anestesiol. 1992; 58(4 Suppl 1):35-42. View

20.

Garcia J, Wagner S, Liu K, Hu X . Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke. 1995; 26(4):627-34; discussion 635. DOI: 10.1161/01.str.26.4.627. View