The Astrocyte As a Gatekeeper of Synaptic Information Transfer

Overview

Journal Neural Comput

Publisher MIT Press

Specialty Medical Informatics

Date 2007 Jan 9

PMID 17206866

Citations 38

Authors

Vladislav Volman

Eshel Ben-Jacob

Herbert Levine

Affiliations

Soon will be listed here.

Abstract

We present a simple biophysical model for the coupling between synaptic transmission and the local calcium concentration on an enveloping astrocytic domain. This interaction enables the astrocyte to modulate the information flow from presynaptic to postsynaptic cells in a manner dependent on previous activity at this and other nearby synapses. Our model suggests a novel, testable hypothesis for the spike timing statistics measured for rapidly firing cells in culture experiments.

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