Blood-brain Barrier Delivery

Overview

Journal Drug Discov Today

Specialty Pharmacology

Date 2007 Jan 3

PMID 17198973

Citations 416

Authors

William M Pardridge

Affiliations

Soon will be listed here.

Abstract

Neuropharmaceutics is the largest potential growth sector of the pharmaceutical industry. However, this growth is blocked by the problem of the blood-brain barrier (BBB). Essentially 100% of large-molecule drugs and >98% of small-molecule drugs do not cross the BBB. The BBB can be traversed because there are multiple endogenous transporters within this barrier. Therefore, brain drug development programs of the future need to be re-configured so that drugs are formulated to enable transport into the brain via endogenous BBB transporters.

Citing Articles

Nanoscale drug formulations for the treatment of Alzheimer's disease progression.

Liu L, He H, Du B, He Y RSC Adv. 2025; 15(6):4031-4078.

PMID: 39926227 PMC: 11803502. DOI: 10.1039/d4ra08128e.

Combined Strategies for Nanodrugs Noninvasively Overcoming the Blood-Brain Barrier and Actively Targeting Glioma Lesions.

Liu Y, Wu H, Liang G Biomater Res. 2025; 29:0133.

PMID: 39911305 PMC: 11794768. DOI: 10.34133/bmr.0133.

Enhancing Antibody Exposure in the Central Nervous System: Mechanisms of Uptake, Clearance, and Strategies for Improved Brain Delivery.

Schwinghamer K, Siahaan T J Nanotheranostics. 2025; 4(4):463-479.

PMID: 39897432 PMC: 11784990. DOI: 10.3390/jnt4040020.

Lanthanide-tetrazine probes for bio-imaging and click chemistry.

Woolley B, Wu Y, Xiong L, Chau H, Zhang J, Law G Chem Sci. 2025; 16(8):3588-3597.

PMID: 39867958 PMC: 11759059. DOI: 10.1039/d4sc02335h.

Drug Delivery Across the Blood-Brain Barrier: A New Strategy for the Treatment of Neurological Diseases.

Jiao Y, Yang L, Wang R, Song G, Fu J, Wang J Pharmaceutics. 2025; 16(12.

PMID: 39771589 PMC: 11677317. DOI: 10.3390/pharmaceutics16121611.