A MyD88-deficient Mouse Model Reveals a Role for Nramp1 in Campylobacter Jejuni Infection

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2006 Dec 30

PMID 17194808

Citations 32

Authors

Robert O Watson

Veronica Novik

Dirk Hofreuter

Maria Lara-Tejero

Jorge E Galan

Affiliations

Soon will be listed here.

Abstract

Campylobacter jejuni is a major worldwide cause of enteric illnesses. Adult immunocompetent mice are not susceptible to C. jejuni infection. However, we show here that mice deficient in the adaptor protein myeloid differentiation factor 88 (MyD88), which is required for signaling through most Toll-like receptors, can be stably colonized by C. jejuni but not by isogenic derivatives carrying mutations in known virulence genes. We also found that Nramp1 deficiency increases the mouse susceptibility to C. jejuni infection when administered systemically. These results indicate that MyD88-deficient mice could be a useful model to study C. jejuni colonization and reveal a potential role for Nramp1 in the control of this bacterial pathogen.

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