Reduced Apoptosis in Human Intestinal Cells Cured of Persistent Poliovirus Infection

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2006 Dec 29

PMID 17192301

Citations 2

Authors

Karine Labadie

Aure Saulnier

Sandra Martin-Latil

Florence Colbere-Garapin

Affiliations

Soon will be listed here.

Abstract

Cells cured of persistent virus infection can be used to investigate cellular pathways of resistance to viral cytopathic effects. Persistent poliovirus (PV) infections were established in human intestinal Caco-2 cells, and spontaneously cured cell cultures were obtained. Two cell clones, cl6 and b13, cured of type 3 PV mutant infection and their parental Caco-2 cells were compared for susceptibility to PV infection, PV receptor CD155 expression, capacity to differentiate into polarized enterocytes, and PV-, staurosporine-, and actinomycin D-induced apoptosis. Our results strongly suggest that cells that are partially resistant to apoptosis can be selected during persistent virus infection.

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