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Anti-tumor-initiating Effects of Monascin, an Azaphilonoid Pigment from the Extract of Monascus Pilosus Fermented Rice (red-mold Rice)

Overview
Journal Chem Biodivers
Specialty Biochemistry
Date 2006 Dec 29
PMID 17191930
Citations 26
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Abstract

Monascin (1) constitutes one of the azaphilonoid pigments in the extracts of Monascus pilosus-fermented rice (red-mold rice). Compound 1 was evaluated for its anti-tumor-initiating activity via oral administration on the two-stage carcinogenesis of mouse skin tumor induced by peroxynitrite (ONOO-; PN) or by ultraviolet light B (UVB) as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. Compound 1 exhibited marked inhibitory activity on both PN- and UVB-induced mouse skin carcinogenesis tests. These findings suggest that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis.

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