Augmentation of Haptoglobin Production in Hep3B Cell Line by a Nuclear Factor NF-IL6

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1991 Oct 7

PMID 1718780

Citations 9

Authors

S Natsuka

H Isshiki

S Akira

T Kishimoto

Affiliations

Soon will be listed here.

Abstract

The nuclear factor NF-IL6 had been suggested to be responsible for the IL-6-mediated induction of several acute-phase proteins. To obtain evidence for the involvement of NF-IL6 in the induction of acute-phase proteins, we introduced the NF-IL6 gene and its truncated mutant (delNFIL6) gene into a hepatoma cell line Hep3B. Then, we examined the effect of the overproduced NF-IL6 and delNFIL6 on the expression of haptoglobin, fibrinogen and albumin. As a result, basal production as well as induction of haptoglobin by IL-6 were augmented by the expression of NF-IL6, whereas delNFIL6 blocked the production of haptoglobin, fibrinogen and albumin.

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