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[Advances in Cardiovascular Medicine Through Molecular Imaging]

Overview
Journal Radiologe
Specialty Radiology
Date 2006 Dec 26
PMID 17187263
Citations 3
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Abstract

We will witness a change of paradigm in cardiovascular imaging, which is empowered by advances in imaging technology, biochemistry, molecular biology and nanotechnology. Instead of simply following the physical distribution of established contrast agents, we now have the opportunity to noninvasively image biological processes such as enzyme activity, interaction with cell surface markers, gene expression and cell migration. These advancements open up new avenues in basic cardiovascular research and will greatly speed up the pace of discovery. Patient management will profit as well: cardiovascular molecular imaging will strengthen personlized and prophylactic medicine through timely and precise diagnostics. In our review we describe selected molecular imaging strategies in atherosclerosis, myocardial ischemia and healing.

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References
1.
Chen J, Tung C, Allport J, Chen S, Weissleder R, Huang P . Near-infrared fluorescent imaging of matrix metalloproteinase activity after myocardial infarction. Circulation. 2005; 111(14):1800-5. PMC: 3733536. DOI: 10.1161/01.CIR.0000160936.91849.9F. View

2.
Weissleder R . Molecular imaging in cancer. Science. 2006; 312(5777):1168-71. DOI: 10.1126/science.1125949. View

3.
Nahrendorf M, Jaffer F, Kelly K, Sosnovik D, Aikawa E, Libby P . Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation. 2006; 114(14):1504-11. DOI: 10.1161/CIRCULATIONAHA.106.646380. View

4.
Meoli D, Sadeghi M, Krassilnikova S, Bourke B, Giordano F, Dione D . Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. J Clin Invest. 2004; 113(12):1684-91. PMC: 420502. DOI: 10.1172/JCI20352. View

5.
Nahrendorf M, Hu K, Frantz S, Jaffer F, Tung C, Hiller K . Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction. Circulation. 2006; 113(9):1196-202. PMC: 4066325. DOI: 10.1161/CIRCULATIONAHA.105.602094. View