Characteristics of Extinction of a Conditioned Passive Avoidance Reflex in Mice with Different Levels of Anxiety

Overview

Journal Neurosci Behav Physiol

Publisher Springer

Date 2006 Dec 21

PMID 17180315

Citations 3

Authors

N I Dubrovina

R A Tomilenko

Affiliations

Soon will be listed here.

Abstract

The relationship between the extinction of a conditioned passive avoidance reflex and the initial anxiety level was studied in mice. The time spent in the open arms of an elevated cross maze was used to classify the mice into high-, intermediate-and low-anxiety individuals. Each level of anxiety was found to correspond to a defined extinction dynamic. Highly anxious mice were characterized by the absence of extinction of the conditioned passive avoidance reflex and stability of good reproduction of the memory trace on testing to as long as 15 days. In intermediately anxious individuals, a deficit in performance of the avoidance reflex appeared from day 7 of extinction. In low-anxiety mice, memory trace reproduction deteriorated from test day 11.

Citing Articles

TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety-related behaviors.

Cho C, Lee S, Kim A, Yarishkin O, Ryoo K, Lee Y EMBO Rep. 2019; 21(2):e48097.

PMID: 31782602 PMC: 7001509. DOI: 10.15252/embr.201948097.

Acquisition and extinction of human avoidance behavior: attenuating effect of safety signals and associations with anxiety vulnerabilities.

Sheynin J, Beck K, Servatius R, Myers C Front Behav Neurosci. 2014; 8:323.

PMID: 25309373 PMC: 4163982. DOI: 10.3389/fnbeh.2014.00323.

Feeding mice with diets containing mercury-contaminated fish flesh from French Guiana: a model for the mercurial intoxication of the Wayana Amerindians.

Bourdineaud J, Bellance N, Benard G, Brethes D, Fujimura M, Gonzalez P Environ Health. 2008; 7:53.

PMID: 18959803 PMC: 2584016. DOI: 10.1186/1476-069X-7-53.

References

Kellett J, Kokkinidis L . Extinction deficit and fear reinstatement after electrical stimulation of the amygdala: implications for kindling-associated fear and anxiety. Neuroscience. 2004; 127(2):277-87. DOI: 10.1016/j.neuroscience.2004.05.011. View

Maren S . Building and burying fear memories in the brain. Neuroscientist. 2005; 11(1):89-99. DOI: 10.1177/1073858404269232. View

Sara S . Retrieval and reconsolidation: toward a neurobiology of remembering. Learn Mem. 2001; 7(2):73-84. DOI: 10.1101/lm.7.2.73. View

Lin C, Yeh S, Lu H, Gean P . The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory. J Neurosci. 2003; 23(23):8310-7. PMC: 6740702. View

Ramos A, Mormede P . Stress and emotionality: a multidimensional and genetic approach. Neurosci Biobehav Rev. 1998; 22(1):33-57. DOI: 10.1016/s0149-7634(97)00001-8. View

Rosen J, Schulkin J . From normal fear to pathological anxiety. Psychol Rev. 1998; 105(2):325-50. DOI: 10.1037/0033-295x.105.2.325. View

Santini E, Ge H, Ren K, Pena de Ortiz S, Quirk G . Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex. J Neurosci. 2004; 24(25):5704-10. PMC: 6729226. DOI: 10.1523/JNEUROSCI.0786-04.2004. View

Ribeiro R, Andreatini R, Wolfman C, Viola H, Medina J, Da Cunha C . The "anxiety state" and its relation with rat models of memory and habituation. Neurobiol Learn Mem. 1999; 72(2):78-94. DOI: 10.1006/nlme.1998.3891. View

Nader K . Memory traces unbound. Trends Neurosci. 2003; 26(2):65-72. DOI: 10.1016/S0166-2236(02)00042-5. View

10.

Beuzen A, Belzung C . Link between emotional memory and anxiety states: a study by principal component analysis. Physiol Behav. 1995; 58(1):111-8. DOI: 10.1016/0031-9384(95)00013-9. View

11.

Laxmi T, Stork O, Pape H . Generalisation of conditioned fear and its behavioural expression in mice. Behav Brain Res. 2003; 145(1-2):89-98. DOI: 10.1016/s0166-4328(03)00101-3. View

12.

Barrett D, Shumake J, Jones D, Gonzalez-Lima F . Metabolic mapping of mouse brain activity after extinction of a conditioned emotional response. J Neurosci. 2003; 23(13):5740-9. PMC: 6741242. View

13.

Rescorla R . Protection from extinction. Learn Behav. 2003; 31(2):124-32. DOI: 10.3758/bf03195975. View

14.

Zhukov D, Vinogradova E . [Different anxiety levels in rats selected for their ability to acquire the conditioned reflex of active avoidance]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1994; 44(3):591-6. View

15.

Lapin I . [A decreased frequency of peeking out from the dark compartment--the only constant index of the effect of anxiogens on the behavior of mice in a "light-darkness" chamber]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1999; 49(3):521-6. View

16.

Cammarota M, Bevilaqua L, Kerr D, Medina J, Izquierdo I . Inhibition of mRNA and protein synthesis in the CA1 region of the dorsal hippocampus blocks reinstallment of an extinguished conditioned fear response. J Neurosci. 2003; 23(3):737-41. PMC: 6741935. View

17.

Podhorna J, Brown R . Strain differences in activity and emotionality do not account for differences in learning and memory performance between C57BL/6 and DBA/2 mice. Genes Brain Behav. 2003; 1(2):96-110. DOI: 10.1034/j.1601-183x.2002.10205.x. View

18.

Rodgers R . Animal models of 'anxiety': where next?. Behav Pharmacol. 1998; 8(6-7):477-96; discussion 497-504. DOI: 10.1097/00008877-199711000-00003. View

19.

Avgustinovich D, Alekseenko O, Popova N . [The behavior of mice from 6 genotypes in 2 tests for anxiety]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1999; 48(6):1080-9. View

20.

Cain C, Blouin A, Barad M . Temporally massed CS presentations generate more fear extinction than spaced presentations. J Exp Psychol Anim Behav Process. 2003; 29(4):323-33. DOI: 10.1037/0097-7403.29.4.323. View