ENOS Phosphorylation: a Pivotal Molecular Switch in Vasodilation and Cardioprotection?

Overview

Journal J Mol Cell Cardiol

Specialty Cardiology & Vascular Diseases

Date 2006 Dec 19

PMID 17174975

Citations 30

Authors

Rakesh C Kukreja

Lei Xi

Affiliations

Soon will be listed here.

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References

Mount P, Kemp B, Power D . Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol. 2006; 42(2):271-9. DOI: 10.1016/j.yjmcc.2006.05.023. View

Gonon A, Bulhak A, Labruto F, Sjoquist P, Pernow J . Cardioprotection mediated by rosiglitazone, a peroxisome proliferator-activated receptor gamma ligand, in relation to nitric oxide. Basic Res Cardiol. 2006; 102(1):80-9. DOI: 10.1007/s00395-006-0613-4. View

Xi L, Kukreja R . Pivotal role of nitric oxide in delayed pharmacological preconditioning against myocardial infarction. Toxicology. 2001; 155(1-3):37-44. DOI: 10.1016/s0300-483x(00)00275-4. View

Hoffmann J, Haendeler J, Aicher A, Rossig L, Vasa M, Zeiher A . Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ Res. 2001; 89(8):709-15. DOI: 10.1161/hh2001.097796. View

Bell R, Yellon D . The contribution of endothelial nitric oxide synthase to early ischaemic preconditioning: the lowering of the preconditioning threshold. An investigation in eNOS knockout mice. Cardiovasc Res. 2001; 52(2):274-80. DOI: 10.1016/s0008-6363(01)00394-7. View

Fulton D, Gratton J, Sessa W . Post-translational control of endothelial nitric oxide synthase: why isn't calcium/calmodulin enough?. J Pharmacol Exp Ther. 2001; 299(3):818-24. View

Gao F, Gao E, Yue T, Ohlstein E, Lopez B, Christopher T . Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation. 2002; 105(12):1497-502. DOI: 10.1161/01.cir.0000012529.00367.0f. View

Bell R, Yellon D . Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway. J Am Coll Cardiol. 2003; 41(3):508-15. DOI: 10.1016/s0735-1097(02)02816-4. View

Bell R, Yellon D . Bradykinin limits infarction when administered as an adjunct to reperfusion in mouse heart: the role of PI3K, Akt and eNOS. J Mol Cell Cardiol. 2003; 35(2):185-93. DOI: 10.1016/s0022-2828(02)00310-3. View

10.

Kone B, Kuncewicz T, Zhang W, Yu Z . Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide. Am J Physiol Renal Physiol. 2003; 285(2):F178-90. DOI: 10.1152/ajprenal.00048.2003. View

11.

Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K . Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med. 2003; 9(11):1370-6. DOI: 10.1038/nm948. View

12.

Tsang A, Hausenloy D, Mocanu M, Yellon D . Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway. Circ Res. 2004; 95(3):230-2. DOI: 10.1161/01.RES.0000138303.76488.fe. View

13.

Wolfrum S, Dendorfer A, Schutt M, Weidtmann B, Heep A, Tempel K . Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway. J Cardiovasc Pharmacol. 2004; 44(3):348-55. DOI: 10.1097/01.fjc.0000137162.14735.30. View

14.

Michel T, Li G, Busconi L . Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1993; 90(13):6252-6. PMC: 46906. DOI: 10.1073/pnas.90.13.6252. View

15.

Corson M, James N, Latta S, Nerem R, Berk B, Harrison D . Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res. 1996; 79(5):984-91. DOI: 10.1161/01.res.79.5.984. View

16.

Bolli R, Manchikalapudi S, Tang X, Takano H, Qiu Y, Guo Y . The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioning. Circ Res. 1997; 81(6):1094-107. DOI: 10.1161/01.res.81.6.1094. View

17.

Tosaki A, Maulik N, Elliott G, Blasig I, Engelman R, Das D . Preconditioning of rat heart with monophosphoryl lipid A: a role for nitric oxide. J Pharmacol Exp Ther. 1998; 285(3):1274-9. View

18.

Chen Z, Mitchelhill K, Michell B, Stapleton D, Rodriguez-Crespo I, Witters L . AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett. 1999; 443(3):285-9. DOI: 10.1016/s0014-5793(98)01705-0. View

19.

Fulton D, Gratton J, McCabe T, Fontana J, Fujio Y, Walsh K . Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999; 399(6736):597-601. PMC: 3637917. DOI: 10.1038/21218. View

20.

Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher A . Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999; 399(6736):601-5. DOI: 10.1038/21224. View