Properties of Tuberomammillary Histamine Neurones and Their Response to Galanin

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1991 May 1

PMID 1716824

Citations 14

Authors

B Schonrock

D Busselberg

H L Haas

Affiliations

Soon will be listed here.

Abstract

Histaminergic neurones in the tuberomammillary nucleus possess electrophysiological properties which distinguish them from other neurones in their neighborhood. Their resting potential is -50 mV and they are spontaneously active at about 2 Hz in a slice preparation. They display a transient outward rectification and an anomalous inward rectification. Bath application of galanin (0.1 microM) reduced their firing rate significantly and hyperpolarized them slightly.

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References

Nilsson T, Arkhammar P, Rorsman P, Berggren P . Suppression of insulin release by galanin and somatostatin is mediated by a G-protein. An effect involving repolarization and reduction in cytoplasmic free Ca2+ concentration. J Biol Chem. 1989; 264(2):973-80. View

Kohler C, Ericson H, Watanabe T, Polak J, PALAY S, Palay V . Galanin immunoreactivity in hypothalamic neurons: further evidence for multiple chemical messengers in the tuberomammillary nucleus. J Comp Neurol. 1986; 250(1):58-64. DOI: 10.1002/cne.902500105. View

Koenig J, Hooi S, Gabriel S, Martin J . Potential involvement of galanin in the regulation of fluid homeostasis in the rat. Regul Pept. 1989; 24(1):81-6. DOI: 10.1016/0167-0115(89)90213-9. View

Greene R, Haas H, Reiner P . Two transient outward currents in histamine neurones of the rat hypothalamus in vitro. J Physiol. 1990; 420:149-63. PMC: 1190042. DOI: 10.1113/jphysiol.1990.sp017905. View

Ottlecz A, Snyder G, McCANN S . Regulatory role of galanin in control of hypothalamic-anterior pituitary function. Proc Natl Acad Sci U S A. 1988; 85(24):9861-5. PMC: 282881. DOI: 10.1073/pnas.85.24.9861. View