Enhancement of Immunity Against Murine Syngeneic Tumors by a Fraction Extracted from Non-pathogenic Mycobacteria

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1975 Sep 1

PMID 171670

Citations 7

Authors

A LAMENSANS

L CHEDID

E Lederer

J P ROSSELET

R H GUSTAFSON

H J Spencer

B Ludwig

F M Berger

Affiliations

Soon will be listed here.

Abstract

The data reported here demonstrate that a preparation extracted from nonpathogenic mycobacteria such as Mycobacterium smegmatis and hereafter referred to as interphase material protected mice against Ehrlich ascitic carcinoma, L-1210 leukemia, and another syngeneic lymphoid leukemia. Furthermore, mice treated by this preparation were much less susceptible to endotoxins than when stimulated by BCG (bacillus Calmette-Guerin) or M. smegmatis cells. Moreover, guinea pigs treated by interphase material administered in Freund's incomplete adjuvant showed an increased immune response, yet their sensitivity to tuberculin was much weaker than that of controls sensitized with Freund's complete adjuvant. Finally, resistance to Columbia SK virus infection could be demonstrated when interphase material was administered to mice prior to virus challenge.

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References

LAMENSANS A, Mollier M, Laurent M . [Effects of B.C.G. on the hepatic catalase activity in mouse. Relation between the reticuloendothelial system and the resistance against grafted AKR leukemia]. Rev Fr Etud Clin Biol. 1968; 13(9):871-6. View

Zbar B, Bernstein I, Tanaka T, Rapp H . Tumor immunity produced by the intradermal inoculation of living tumor cells and living Mycobacterium bovis (strain BCG). Science. 1970; 170(3963):1217-8. DOI: 10.1126/science.170.3963.1217. View

. Immunological aspects of neoplasia: a rational basis for immunotherapy. Ann Intern Med. 1971; 74(4):587-604. DOI: 10.7326/0003-4819-74-4-587. View

Bekierkunst A, LEVIJ I, Yarkoni E, VILKAS E, Lederer E . Cellular reaction in the footpad and draining lymph nodes of mice induced by mycobacterial fractions and BCG bacilli. Infect Immun. 1971; 4(3):245-55. PMC: 416296. DOI: 10.1128/iai.4.3.245-255.1971. View

Bekierkunst A, LEVIJ I, Yarkoni E . Suppression of urethan-induced lung adenomas in mice treated with trehalose-6,6-dimycolate (cord factor) and living bacillus Calmette Guérin. Science. 1971; 174(4015):1240-2. DOI: 10.1126/science.174.4015.1240. View

Erikson U, Hjelmstedt A . Roentgenologic aspects of BCG-osteomyelitis. Radiology. 1971; 101(3):575-8. DOI: 10.1148/101.3.575. View

SUTER E, ULLMAN G, Hoffman R . Sensitivity of mice to endotoxin after vaccination with BCG (Bacillus Calmette-Guérin). Proc Soc Exp Biol Med. 1958; 99(1):167-9. DOI: 10.3181/00379727-99-24282. View

Weiss D, BONHAG R, DeOME K . Protective activity of fractions of tubercle bacilli against isologous tumours in mice. Nature. 1961; 190:889-91. DOI: 10.1038/190889a0. View

BIOZZI G, STIFFEL C, HALPERN B, Mouton D . [Effect of inoculation with Calmette-Guerin bacillus on the development of Ehrlich ascites tumor in the mouse]. C R Seances Soc Biol Fil. 1959; 153:987-9. View

10.

Old L, CLARKE D, Benacerraf B . Effect of Bacillus Calmette-Guerin infection on transplanted tumours in the mouse. Nature. 1959; 184(Suppl 5):291-2. DOI: 10.1038/184291a0. View

11.

Bekierkunst A, Wang L, Toubiana R, Lederer E . Immunotherapy of Cancer with Nonliving BCG and Fractions Derived from Mycobacteria: Role of Cord Factor (Trehalose-6, 6'-Dimycolate) in Tumor Regression. Infect Immun. 1974; 10(5):1044-50. PMC: 423059. DOI: 10.1128/iai.10.5.1044-1050.1974. View

12.

Modolell M, Luckenbach G, Parant M, MUNDER P . The adjuvant activity of a mycobacterial water soluble adjuvant (WSA) in vitro. I. The requirement of macrophages. J Immunol. 1974; 113(1):395-403. View

13.

Juy D, Bona C, CHEDID L . [Antitumoral effect of peritoneal macrophages activated by a water-soluble adjuvant of mycobacterial origin]. C R Acad Hebd Seances Acad Sci D. 1974; 278(22):2859-62. View

14.

TOULLET F, Audibert F, CHEDID L, VOISIN G . [Use of a water-soluble adjuvant fraction from "Mycobacterium smegmatis" with sperm extract to induce autoimmune aspermatogenic orchiepididymitis in guniea pigs (author's transl)]. Ann Immunol (Paris). 1974; 125(6):901-10. View

15.

Weiss D, BONHAG R, Leslie P . Studies on the heterologous immunogenicity of a methanol-insoluble fraction of attenuated tubercle bacilli (BCG). II. Protection against tumor isografts. J Exp Med. 1966; 124(6):1039-65. PMC: 2138325. DOI: 10.1084/jem.124.6.1039. View

16.

MATHE G . Active immunotherapy. Adv Cancer Res. 1971; 14:1-36. DOI: 10.1016/s0065-230x(08)60517-5. View

17.

CHEDID L, Parant M, Parant F, GUSTAFSON R, Berger F . Biological study of a nontoxic, water-soluble immunoadjuvant from mycobacterial cell walls. Proc Natl Acad Sci U S A. 1972; 69(4):855-8. PMC: 426580. DOI: 10.1073/pnas.69.4.855. View

18.

Meyer T, Ribi E, Azuma I, Zbar B . Biologically active components from mycobacterial cell walls. II. Suppression and regression of strain-2 guinea pig hepatoma. J Natl Cancer Inst. 1974; 52(1):103-11. DOI: 10.1093/jnci/52.1.103. View

19.

Adam A, Ciorbaru R, PETIT J, Lederer E . Isolation and properties of a macromolecular, water-soluble, immuno-adjuvant fraction from the cell wall of Mycobacterium smegmatis. Proc Natl Acad Sci U S A. 1972; 69(4):851-4. PMC: 426579. DOI: 10.1073/pnas.69.4.851. View

20.

Hiu I . Water-soluble and lipid-free fraction from BCG with adjuvant and antitumour activity. Nat New Biol. 1972; 238(86):241-2. DOI: 10.1038/newbio238241a0. View