Argyrophilic Nucleolar Organiser Region Counts and Prognosis in Pharyngeal Carcinoma

Overview

Journal Br J Cancer

Specialty Oncology

Date 1991 Aug 1

PMID 1716455

Citations 6

Authors

A Pich

P Pisani

M Kzengli

N Cappello

R Navone

Affiliations

Soon will be listed here.

Abstract

The prognostic significance of argyrophilic nucleolar organiser regions (AgNORs) has been evaluated in biopsy specimens from 61 primary squamous and undifferentiated carcinomas of the pharynx prior to therapy. The univariate Kaplan-Meyer survival analysis showed a significant correlation between 3- and 5-year survival rates and the mean AgNOR number per tumour cell (P less than 0.001). No significant correlation was found between prognosis and patients age and sex, tumour location, clinical stage, histologic grade, extent of lymphocytic infiltration, HMFG-2 positivity of tumour cells and UCHL1, LN2, MB2 positivity of infiltrating lymphocytes. There was no significant association between AgNOR counts and tumour histologic grade or clinical stage. Multivariate survival analysis showed that only two variables were significantly correlated with prognosis: AgNOR counts (P less than 0.001) and the extent of lymphocytic infiltration (P less than 0.027). Our results indicate the prognostic value of AgNOR counts and suggest the use of this method as a significant parameter in the pretherapeutic assessment of the aggressiveness of pharyngeal carcinomas.

Citing Articles

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Proliferative activity is a significant prognostic factor in male breast carcinoma.

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Ag-NOR protein distribution correlates with patient survival in stage I endometrial adenocarcinoma.

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References

Bryan R, Allcock R, Crocker J, Shenoi P . Nucleolar organiser regions in squamous tumours of the pharynx and larynx. J Clin Pathol. 1989; 42(2):218. PMC: 1141835. DOI: 10.1136/jcp.42.2.218. View

McNicol A, Colgan J, McMeekin W, Teasdale G . Nucleolar organiser regions in pituitary adenomas. Acta Neuropathol. 1989; 77(5):547-9. DOI: 10.1007/BF00687257. View

Derenzini M, Romagnoli T, Mingazzini P, MARINOZZI V . Interphasic nucleolar organizer region distribution as a diagnostic parameter to differentiate benign from malignant epithelial tumors of human intestine. Virchows Arch B Cell Pathol Incl Mol Pathol. 1988; 54(6):334-40. DOI: 10.1007/BF02899231. View

Nairn E, Crocker J, McGovern J . Limited value of AgNOR enumeration in assessment of thyroid neoplasms. J Clin Pathol. 1988; 41(10):1136. PMC: 1141706. DOI: 10.1136/jcp.41.10.1136-a. View

Egan M, Raafat F, Crocker J, Williams D . Comparative study of the degree of differentiation of neuroblastoma and mean numbers of nucleolar organiser regions. J Clin Pathol. 1988; 41(5):527-31. PMC: 1141505. DOI: 10.1136/jcp.41.5.527. View

Wolf G, Makuch R, Baker S . Predictive factors for tumor response to preoperative chemotherapy in patients with head and neck squamous carcinoma. The Head and Neck Contracts Program. Cancer. 1984; 54(12):2869-77. DOI: 10.1002/1097-0142(19841215)54:12<2869::aid-cncr2820541210>3.0.co;2-n. View

Crissman J, Liu W, Gluckman J, Cummings G . Prognostic value of histopathologic parameters in squamous cell carcinoma of the oropharynx. Cancer. 1984; 54(12):2995-3001. DOI: 10.1002/1097-0142(19841215)54:12<2995::aid-cncr2820541230>3.0.co;2-r. View

Cohen P, Lotze M, Roberts J, Rosenberg S, Jaffe E . The immunopathology of sequential tumor biopsies in patients treated with interleukin-2. Correlation of response with T-cell infiltration and HLA-DR expression. Am J Pathol. 1987; 129(2):208-16. PMC: 1899728. View

Crocker J, Skilbeck N . Nucleolar organiser region associated proteins in cutaneous melanotic lesions: a quantitative study. J Clin Pathol. 1987; 40(8):885-9. PMC: 1141130. DOI: 10.1136/jcp.40.8.885. View

10.

Moore C, Flynn M, Greenberg R . Evaluation of size in prognosis of oral cancer. Cancer. 1986; 58(1):158-62. DOI: 10.1002/1097-0142(19860701)58:1<158::aid-cncr2820580127>3.0.co;2-b. View

11.

Derenzini M, Pession A, Trere D . Quantity of nucleolar silver-stained proteins is related to proliferating activity in cancer cells. Lab Invest. 1990; 63(1):137-40. View

12.

Sivridis E, Sims B . Nucleolar organiser regions: new prognostic variable in breast carcinomas. J Clin Pathol. 1990; 43(5):390-2. PMC: 502439. DOI: 10.1136/jcp.43.5.390. View

13.

Ruschoff J, Bittinger A, Neumann K, SCHMITZ-MOORMANN P . Prognostic significance of nucleolar organizing regions (NORs) in carcinomas of the sigmoid colon and rectum. Pathol Res Pract. 1990; 186(1):85-91. DOI: 10.1016/S0344-0338(11)81014-9. View

14.

Suresh U, Chawner L, Buckley C, Fox H . Do AgNOR counts reflect cellular ploidy or cellular proliferation? A study of trophoblastic tissue. J Pathol. 1990; 160(3):213-5. DOI: 10.1002/path.1711600306. View

15.

Hansen A, Ostergard B . AgNOR counts in intraendometrial neoplasia. J Clin Pathol. 1990; 43(6):518-9. PMC: 502513. DOI: 10.1136/jcp.43.6.518-b. View

16.

Bryan R, Crocker J, Farr A . Nucleolar organiser regions in kidney tumours and xanthogranulomatous pyelonephritis. J Clin Pathol. 1990; 43(2):147-8. PMC: 502297. DOI: 10.1136/jcp.43.2.147. View

17.

Hsu S, RAINE L, FANGER H . Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981; 29(4):577-80. DOI: 10.1177/29.4.6166661. View

18.

Shimokawara I, Imamura M, Yamanaka N, Ishii Y, Kikuchi K . Identification of lymphocyte subpopulations in human breast cancer tissue and its significance: an immunoperoxidase study with anti-human T- and B-cell sera. Cancer. 1982; 49(7):1456-64. DOI: 10.1002/1097-0142(19820401)49:7<1456::aid-cncr2820490724>3.0.co;2-#. View

19.

Taylor-Papadimitriou J, Peterson J, Arklie J, Burchell J, Ceriani R, Bodmer W . Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture. Int J Cancer. 1981; 28(1):17-21. DOI: 10.1002/ijc.2910280104. View

20.

Shanmugaratnam K, Chan S, Goh J, Khor T, SIMONS M, TYE C . Histopathology of nasopharyngeal carcinoma: correlations with epidemiology, survival rates and other biological characteristics. Cancer. 1979; 44(3):1029-44. DOI: 10.1002/1097-0142(197909)44:3<1029::aid-cncr2820440335>3.0.co;2-5. View