Mechanosensitive Ion Channels and the Peptide Inhibitor GsMTx-4: History, Properties, Mechanisms and Pharmacology

Overview

Journal Toxicon

Specialty Toxicology

Date 2006 Dec 13

PMID 17157345

Citations 93

Authors

Charles L Bowman

Philip A Gottlieb

Thomas M Suchyna

Yolanda K Murphy

Frederick Sachs

Affiliations

Soon will be listed here.

Abstract

Sensing the energy from mechanical inputs is ubiquitous--and perhaps the oldest form of biological energy transduction. However, the tools available to probe the mechanisms of transduction are far fewer than for the chemical and electric field sensitive transducers. The one pharmacological tool available for mechansensitive ion channels (MSCs) is a peptide (GsMTx-4) isolated from venom of the tarantula, Grammostola spatulata, that blocks cationic MSCs found in non-specialized eukaryotic tissues. In this review, we summarize the current knowledge of GsMTx-4, and discuss the inevitable crosstalk between the MSC behavior and the mechanical properties of the cell cortex.

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