Hypervirulence of a Rough Variant of the Mycobacterium Abscessus Type Strain

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2006 Dec 6

PMID 17145951

Citations 101

Authors

E Catherinot

J Clarissou

G Etienne

F Ripoll

J-F Emile

M Daffe

C Perronne

C Soudais

J-L Gaillard

M Rottman

Affiliations

Soon will be listed here.

Abstract

We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.

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