The Long Term Effects of Chemotherapy on the Central Nervous System

Overview

Journal J Biol

Publisher Biomed Central

Specialty Biology

Date 2006 Dec 5

PMID 17140427

Citations 6

Authors

Patricia K Duffner

Affiliations

Soon will be listed here.

Abstract

Cranial radiotherapy is known to have adverse effects on intelligence. A new study shows that chemotherapy is also toxic to the central nervous system, especially to neural progenitor cells and oligodendrocytes. By identifying the cell populations at risk, these results may help explain the neurological problems previously seen after chemotherapy.

Citing Articles

Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons.

Lobanova A, She R, Pieraut S, Clapp C, Maximov A, Denchi E Genes Dev. 2017; 31(7):639-647.

PMID: 28428263 PMC: 5411705. DOI: 10.1101/gad.295402.116.

Decreased postural control in adult survivors of childhood cancer treated with chemotherapy.

Einarsson E, Patel M, Petersen H, Wiebe T, Fransson P, Magnusson M Sci Rep. 2016; 6:36784.

PMID: 27830766 PMC: 5103202. DOI: 10.1038/srep36784.

Attenuation of Cisplatin-Induced Neurotoxicity by Cyanidin, a Natural Inhibitor of ROS-Mediated Apoptosis in PC12 Cells.

Li D, Sun J, Wang K, Zhang S, Hou Y, Yang M Cell Mol Neurobiol. 2015; 35(7):995-1001.

PMID: 25895624 PMC: 11488056. DOI: 10.1007/s10571-015-0194-6.

D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat.

Hinduja S, Kraus K, Manohar S, Salvi R Neurotox Res. 2014; 27(3):199-204.

PMID: 25488710 PMC: 4376112. DOI: 10.1007/s12640-014-9503-y.

Evaluation of multiple neurotoxic outcomes in cancer chemotherapy.

Weiss B Adv Exp Med Biol. 2010; 678:96-112.

PMID: 20738011 PMC: 3787700. DOI: 10.1007/978-1-4419-6306-2_13.

References

Packer R, Goldwein J, Nicholson H, Vezina L, Allen J, Ris M . Treatment of children with medulloblastomas with reduced-dose craniospinal radiation therapy and adjuvant chemotherapy: A Children's Cancer Group Study. J Clin Oncol. 1999; 17(7):2127-36. DOI: 10.1200/JCO.1999.17.7.2127. View

Mulhern R, Palmer S, Reddick W, Glass J, Kun L, Taylor J . Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss. J Clin Oncol. 2001; 19(2):472-9. DOI: 10.1200/JCO.2001.19.2.472. View

Poplack D, Pizzo P, Adornato B, DI CHIRO G . Abnormal CT scans of the brain in asymptomatic children with acute lymphocytic leukemia after prophylactic treatment of the central nervous system with radiation and intrathecal chemotherapy. N Engl J Med. 1978; 298(15):815-8. DOI: 10.1056/NEJM197804132981504. View

Hirsch J, Renier D, Czernichow P, Benveniste L, Pierre-Kahn A . Medulloblastoma in childhood. Survival and functional results. Acta Neurochir (Wien). 1979; 48(1-2):1-15. DOI: 10.1007/BF01406016. View

Duffner P, Cohen M, Thomas P . Late effects of treatment on the intelligence of children with posterior fossa tumors. Cancer. 1983; 51(2):233-7. DOI: 10.1002/1097-0142(19830115)51:2<233::aid-cncr2820510211>3.0.co;2-8. View

Duffner P, Cohen M, Brecher M, Berger P, Parthasarathy K, Bakshi S . CT abnormalities and altered methotrexate clearance in children with CNS leukemia. Neurology. 1984; 34(2):229-33. DOI: 10.1212/wnl.34.2.229. View

Rowland J, Glidewell O, Sibley R, Holland J, Tull R, Berman A . Effects of different forms of central nervous system prophylaxis on neuropsychologic function in childhood leukemia. J Clin Oncol. 1984; 2(12):1327-35. DOI: 10.1200/JCO.1984.2.12.1327. View

Duffner P, Cohen M, Parker M . Prospective intellectual testing in children with brain tumors. Ann Neurol. 1988; 23(6):575-9. DOI: 10.1002/ana.410230608. View

Packer R, Sutton L, Atkins T, Radcliffe J, Bunin G, DAngio G . A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemotherapy: 2-year results. J Neurosurg. 1989; 70(5):707-13. DOI: 10.3171/jns.1989.70.5.0707. View

10.

Duffner P, Horowitz M, Krischer J, Friedman H, Burger P, Cohen M . Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med. 1993; 328(24):1725-31. DOI: 10.1056/NEJM199306173282401. View

11.

Mahoney Jr D, Shuster J, Nitschke R, Lauer S, Steuber C, Winick N . Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy--a Pediatric Oncology Group study. J Clin Oncol. 1998; 16(5):1712-22. DOI: 10.1200/JCO.1998.16.5.1712. View

12.

Duffner P . Long-term effects of radiation therapy on cognitive and endocrine function in children with leukemia and brain tumors. Neurologist. 2004; 10(6):293-310. DOI: 10.1097/01.nrl.0000144287.35993.96. View

13.

Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N . Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005; 352(10):978-86. DOI: 10.1056/NEJMoa042176. View

14.

Dietrich J, Han R, Yang Y, Mayer-Proschel M, Noble M . CNS progenitor cells and oligodendrocytes are targets of chemotherapeutic agents in vitro and in vivo. J Biol. 2006; 5(7):22. PMC: 2000477. DOI: 10.1186/jbiol50. View