Striatal Restricted Adenosine A2 Receptor (RDC8) is Expressed by Enkephalin but Not by Substance P Neurons: an in Situ Hybridization Histochemistry Study

Overview

Journal J Neurochem

Specialties Chemistry
Neurology

Date 1991 Sep 1

PMID 1713612

Citations 132

Authors

S N Schiffmann

O Jacobs

J J Vanderhaeghen

Affiliations

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Abstract

RDC8 has been recently cloned and characterized as an adenosine A2 receptor. This receptor is expressed exclusively by medium-sized neurons of the striatum as demonstrated by in situ hybridization. We have now studied the relationship of this receptor with three major components of the rat caudate-putamen: enkephalin, substance P, and choline acetyltransferase. Our results demonstrate that the adenosine A2 receptor is expressed exclusively by the enkephalinergic striatal subpopulation but not by the substance P-containing or cholinergic neurons.

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