Mutations in BHD and TP53 Genes, but Not in HNF1beta Gene, in a Large Series of Sporadic Chromophobe Renal Cell Carcinoma

Overview

Journal Br J Cancer

Specialty Oncology

Date 2006 Nov 30

PMID 17133269

Citations 32

Authors

S Gad

S H Lefevre

S K Khoo

S Giraud

A Vieillefond

V Vasiliu

S Ferlicot

V Molinie

Y Denoux

N Thiounn

Y Chretien

A Mejean

M Zerbib

G Benoit

J M Herve

G Allegre

B Bressac-de Paillerets

B T Teh

S Richard

Affiliations

Soon will be listed here.

Abstract

BHD, TP53, and HNF1beta on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1beta mutations, (84% mutations involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype.

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