CD62 and Endothelial Cell-leukocyte Adhesion Molecule 1 (ELAM-1) Recognize the Same Carbohydrate Ligand, Sialyl-Lewis X

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1991 Jul 15

PMID 1712483

Citations 110

Authors

M J Polley

M L Phillips

E Wayner

E Nudelman

A K Singhal

S Hakomori

J C Paulson

Affiliations

Soon will be listed here.

Abstract

The leukocyte receptor CD62, which is expressed on activated platelets and endothelial cells, is shown to mediate cell adhesion by binding a sialylated carbohydrate structure, sialyl-Lewis x, found on neutrophils, monocytes, and tumor cells. This structure has previously been identified as the ligand for another member of the LEC-CAM family of cell adhesion molecules, endothelial cell-leukocyte adhesion molecule 1, which also binds neutrophils and monocytes. The results demonstrate that although the two LEC-CAMs differ in their biological activities by their distribution and mode of expression, they are capable of mediating cell adhesion by recognition of the same carbohydrate ligand.

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