The Molecular Basis of Neurosensory Cell Formation in Ear Development: a Blueprint for Hair Cell and Sensory Neuron Regeneration?

Overview

Journal Bioessays

Publisher Wiley

Specialties Biology
Cell Biology
Molecular Biology

Date 2006 Nov 23

PMID 17120192

Citations 66

Authors

Bernd Fritzsch

Kirk W Beisel

Laura A Hansen

Affiliations

Soon will be listed here.

Abstract

The inner ear of mammals uses neurosensory cells derived from the embryonic ear for mechanoelectric transduction of vestibular and auditory stimuli (the hair cells) and conducts this information to the brain via sensory neurons. As with most other neurons of mammals, lost hair cells and sensory neurons are not spontaneously replaced and result instead in age-dependent progressive hearing loss. We review the molecular basis of neurosensory development in the mouse ear to provide a blueprint for possible enhancement of therapeutically useful transformation of stem cells into lost neurosensory cells. We identify several readily available adult sources of stem cells that express, like the ectoderm-derived ear, genes known to be essential for ear development. Use of these stem cells combined with molecular insights into neurosensory cell specification and proliferation regulation of the ear, might allow for neurosensory regeneration of mammalian ears in the near future.

Citing Articles

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Gata3 is required in late proneurosensory development for proper sensory cell formation and organization.

Blinkiewicz P, Long M, Stoner Z, Ketchum E, Sheltz-Kempf S, Duncan J Sci Rep. 2023; 13(1):12573.

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Gata3 is Required in Late Proneurosensory Development for Proper Sensory Cell Formation and Organization.

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Elliott K, Fritzsch B, Yamoah E, Zine A Front Aging Neurosci. 2022; 14:814528.

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Embryology, Malformations, and Rare Diseases of the Cochlea.

Warnecke A, Giesemann A Laryngorhinootologie. 2021; 100(S 01):S1-S43.

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