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» Articles » PMID: 17119913

Modeling Segregation Distortion for Viability Selection. I. Reconstruction of Linkage Maps with Distorted Markers

Overview
Journal Theor Appl Genet
Publisher Springer
Specialty Genetics
Date 2006 Nov 23
PMID 17119913
Citations 27
Authors
Chengsong Zhu
Chunming Wang
Yuan-Ming Zhang
Affiliations
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Abstract

Molecular markers have been widely used to map quantitative trait loci (QTL). The QTL mapping partly relies on accurate linkage maps. The non-Mendelian segregation of markers, which affects not only the estimation of genetic distance between two markers but also the order of markers on a same linkage group, is usually observed in QTL analysis. However, these distorted markers are often ignored in the real data analysis of QTL mapping so that some important information may be lost. In this paper, we developed a multipoint approach via Hidden Markov chain model to reconstruct the linkage maps given a specified gene order while simultaneously making use of distorted, dominant and missing markers in an F(2) population. The new method was compared with the methods in the MapManager and Mapmaker programs, respectively, and verified by a series of Monte Carlo simulation experiments along with a working example. Results showed that the adjusted linkage maps can be used for further QTL or segregation distortion locus (SDL) analysis unless there are strong evidences to prove that all markers show normal Mendelian segregation.

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