Donor-type Myelodysplastic Syndrome with T(2;3) and Monosomy 7 After Allogeneic Peripheral Blood Stem Cell Transplantation and Liver Transplantation in a Patient with Severe-type Aplastic Anemia

Overview

Journal Int J Hematol

Specialty Hematology

Date 2006 Nov 23

PMID 17118765

Citations 6

Authors

Satoshi Hashino

Fumie Fujisawa

Takeshi Kondo

Masahiro Imamura

Kazuya Sato

Yoshihiro Torimoto

Yutaka Kohgo

Keisuke Kimura

Hiroyuki Furukawa

Satoru Todo

Masahiro Asaka

Affiliations

Soon will be listed here.

Abstract

Secondary clonal hemaloiogical disease in donor cells has rarely been reported as a complication of allogeneic stem cell transplantation in hematological disease. We report a case of myelodysplastic syndrome that showed cytogenetic abnormalities of t(2;3) and monosomy 7, which developed 2 years after peripheral blood stem cell transplantation for aplastic anemia and 1 year after liver transplantation for drug-induced hepatic failure. This secondary malignancy of donor origin is most frequently seen in patients with leukemia. We suspect that the chromosomal abnormalities are related to hepatitis-associated aplastic anemia, administration of granulocyte colony-stimulating factor and erythropoietin for posttransplantion pancytopenia, and repeated infections after liver transplantation.

Citing Articles

Lessons Learned from Donor Cell-Derived Myeloid Neoplasms: Report of Three Cases and Review of the Literature.

Deshmukh K, Kelemen K Life (Basel). 2022; 12(4).

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Genetics of donor cell leukemia in acute myelogenous leukemia and myelodysplastic syndrome.

Williams L, Doucette K, Karp J, Lai C Bone Marrow Transplant. 2021; 56(7):1535-1549.

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Leukemic Transformation of Severe Aplastic Anemia Following Matched Allogenic Stem Cell Transplantation, Transplanted Again in CR 1.

Manivannan P, Purohit A, Somasundaram V, Ahuja A, Aggarwal M, Kumar R Indian J Hematol Blood Transfus. 2016; 32(Suppl 1):223-7.

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Development of donor cell leukemia following peripheral blood stem cell transplantation for severe aplastic anemia: A case report.

Ma H, Liu T Oncol Lett. 2016; 11(6):3858-3862.

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Monosomy 7 in donor cell-derived leukemia after bone marrow transplantation for severe aplastic anemia: Report of a new case and review of the literature.

Otero L, Correa de Souza D, de Cassia Tavares R, Gomes B, Padilha T, Bouzas L Genet Mol Biol. 2012; 35(4):734-6.

PMID: 23271931 PMC: 3526078. DOI: 10.1590/S1415-47572012005000056.

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