Lack of Association of Interleukin-6 and Interleukin-8 Gene Polymorphisms in Chinese Patients with Systemic Lupus Erythematosus

Overview

Journal J Clin Lab Anal

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
Pathology

Date 2006 Nov 23

PMID 17115422

Citations 8

Authors

Chung-Ming Huang

An-Ping Huo

Chang-Hai Tsai

Chi-Lan Chen

Fuu-Jen Tsai

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to determine whether interleukin (IL)-6 and IL-8 gene polymorphisms were markers of susceptibility to or severity of systemic lupus erythematosus (SLE) in Chinese patients. The study included 150 Chinese patients with SLE. A total of 130 unrelated healthy individuals living in central Taiwan served as control subjects. Polymorphisms of the IL-6 and IL-8 gene were typed from genomic DNA. The genotypes, allelic frequencies, and carriage rates were compared between SLE patients and control subjects. The relationship between allelic frequencies and clinical manifestations of 135 SLE patients was evaluated. There were no statistically significant differences in IL-6 and IL-8 gene polymorphisms between the SLE and control groups (chi-squared test, P=0.53, chi(2)=1.27 and P=0.44, chi(2)=1.62, respectively). In addition, there was no significant association between the two groups in allelic frequency of IL-6 and IL-8 (P=0.89 and P=0.26, respectively). We also did not detect any association between the IL-6 and IL-8 genotype and clinical or laboratory profiles in SLE patients. The results suggest that the IL-6 and IL-8 gene polymorphisms are not related to SLE.

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References

Klinman D, Steinberg A . Systemic autoimmune disease arises from polyclonal B cell activation. J Exp Med. 1987; 165(6):1755-60. PMC: 2188353. DOI: 10.1084/jem.165.6.1755. View

Sekikawa T, Kashihara N, Maruyama K, Satoh M, Okamoto K, Kanao K . Expression of interleukin-8 in human glomerulonephritis. Res Commun Mol Pathol Pharmacol. 1998; 99(2):217-24. View

Mukaida N, Shiroo M, Matsushima K . Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8. J Immunol. 1989; 143(4):1366-71. View

Terry C, Loukaci V, Green F . Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem. 2000; 275(24):18138-44. DOI: 10.1074/jbc.M000379200. View

Ishihara K, Hirano T . IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 2002; 13(4-5):357-68. DOI: 10.1016/s1359-6101(02)00027-8. View

Ripley B, Goncalves B, Isenberg D, Latchman D, Rahman A . Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia. Ann Rheum Dis. 2005; 64(6):849-53. PMC: 1755543. DOI: 10.1136/ard.2004.022681. View

Linker-Israeli M, Deans R, Wallace D, Prehn J, Klinenberg J . Elevated levels of endogenous IL-6 in systemic lupus erythematosus. A putative role in pathogenesis. J Immunol. 1991; 147(1):117-23. View

Linker-Israeli M, Wallace D, Prehn J, Michael D, Honda M, Taylor K . Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression. Genes Immun. 2001; 1(1):45-52. DOI: 10.1038/sj.gene.6363631. View

Houssiau F, Devogelaer J, Van Damme J, de Deuxchaisnes C, Van Snick J . Interleukin-6 in synovial fluid and serum of patients with rheumatoid arthritis and other inflammatory arthritides. Arthritis Rheum. 1988; 31(6):784-8. DOI: 10.1002/art.1780310614. View

10.

Rovin B, Lu L, Zhang X . A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritis. Kidney Int. 2002; 62(1):261-5. DOI: 10.1046/j.1523-1755.2002.00438.x. View

11.

Yokoyama H, Wada T, Furuichi K, Segawa C, Shimizu M, Kobayashi K . Urinary levels of chemokines (MCAF/MCP-1, IL-8) reflect distinct disease activities and phases of human IgA nephropathy. J Leukoc Biol. 1998; 63(4):493-9. DOI: 10.1002/jlb.63.4.493. View

12.

Tan E, Cohen A, Fries J, MASI A, McShane D, Rothfield N . The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982; 25(11):1271-7. DOI: 10.1002/art.1780251101. View

13.

Roebuck K . Regulation of interleukin-8 gene expression. J Interferon Cytokine Res. 1999; 19(5):429-38. DOI: 10.1089/107999099313866. View

14.

Brozik M, Rosztoczy I, Meretey K, Balint G, Gaal M, Balogh Z . Interleukin 6 levels in synovial fluids of patients with different arthritides: correlation with local IgM rheumatoid factor and systemic acute phase protein production. J Rheumatol. 1992; 19(1):63-8. View

15.

Baggiolini M, DEWALD B, Moser B . Interleukin-8 and related chemotactic cytokines--CXC and CC chemokines. Adv Immunol. 1994; 55:97-179. View

16.

Amoli M, Thomson W, Hajeer A, Calvino M, Garcia-Porrua C, Ollier W . Interleukin 8 gene polymorphism is associated with increased risk of nephritis in cutaneous vasculitis. J Rheumatol. 2002; 29(11):2367-70. View

17.

Cockwell P, Brooks C, Adu D, Savage C . Interleukin-8: A pathogenetic role in antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. Kidney Int. 1999; 55(3):852-63. DOI: 10.1046/j.1523-1755.1999.055003852.x. View

18.

Finck B, Chan B, Wofsy D . Interleukin 6 promotes murine lupus in NZB/NZW F1 mice. J Clin Invest. 1994; 94(2):585-91. PMC: 296134. DOI: 10.1172/JCI117373. View

19.

Fugger L, Morling N, Bendtzen K, Ryder L, Andersen V, Heilman C . IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes. J Immunogenet. 1989; 16(6):461-5. DOI: 10.1111/j.1744-313x.1989.tb00495.x. View

20.

Chung H, Seo J, Hur S, Kim H, Kim J, Jung J . Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women. J Hum Genet. 2003; 48(5):243-248. DOI: 10.1007/s10038-003-0020-8. View