Quantitative Linkage Genome Scan for Atopy in a Large Collection of Caucasian Families

Overview

Journal Hum Genet

Specialty Genetics

Date 2006 Nov 15

PMID 17103228

Citations 5

Authors

Bradley T Webb

Edwin van den Oord

Anthony Akkari

Steve Wilton

Tina Ly

Rachael Duff

Kathleen C Barnes

Karin Carlsen

Jorrit Gerritsen

Warren Lenney

Michael Silverman

Peter Sly

John Sundy

John Tsanakas

Andrea von Berg

Moira Whyte

Malcolm Blumenthal

Jorgen Vestbo

Lefkos Middleton

Peter J Helms

Wayne H Anderson

Sreekumar G Pillai

Affiliations

Soon will be listed here.

Abstract

Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPT(per)) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPT(per) which represents 690 independent families. Suggestive linkage (LOD > or = 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPT(per)), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPT(per)) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders.

Citing Articles

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