Lupus Patients with Pulmonary Involvement Have a Pro-inflammatory Cytokines Profile

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 2006 Nov 15

PMID 17103171

Citations 13

Authors

Sana Al-Mutairi

Adel Al-Awadhi

Raj Raghupathy

Hanaa Al-Khawari

Prio Sada

Adeebah Al-Herz

Parvez Rawoot

Affiliations

Soon will be listed here.

Abstract

Objectives: The literature on cytokine response in systemic lupus erythematosus (SLE) is confusing. It is possible that different disease phenotypes have different cytokine profiles. Our aim was to examine the levels of selected pro-inflammatory and anti-inflammatory cytokines in SLE patients with and without pulmonary involvement.

Methods And Subjects: Patients with SLE were interviewed and were subjected to the pulmonary function test and high-resolution computed tomography studies. Serum levels of interleukin (IL)-6, IL-8, IL-10, Il-12, interferon (IFN) gamma, and tumor necrosis factor (TNF) alpha were estimated by enzyme-linked immunosorbent assay.

Results: Forty-nine of the 61 SLE patients had pulmonary involvement. Median levels of IL-8, IFNgamma, and TNFalpha were significantly higher in the pulmonary group as compared to the non-pulmonary group (p = 0.027, 0.027 and 0.002, respectively). Ratios of pro-inflammatory cytokines to anti-inflammatory cytokines were higher in the pulmonary group as compared to the non-pulmonary group as well as in the pulmonary restrictive subgroup compared to the obstructive subgroup.

Conclusion: Lupus patients with pulmonary involvement have a stronger pro-inflammatory cytokine bias than those without pulmonary involvement.

Citing Articles

Cytokines in Systemic Lupus Erythematosus-Focus on TNF-α and IL-17.

Richter P, Macovei L, Mihai I, Cardoneanu A, Burlui M, Rezus E Int J Mol Sci. 2023; 24(19).

PMID: 37833861 PMC: 10572174. DOI: 10.3390/ijms241914413.

Interstitial Lung Disease in Systemic Lupus Erythematosus and Systemic Sclerosis: How Can We Manage the Challenge?.

Richter P, Cardoneanu A, Dima N, Bratoiu I, Rezus C, Burlui A Int J Mol Sci. 2023; 24(11).

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Targeting type I interferons in systemic lupus erythematous.

Bruera S, Chavula T, Madan R, Agarwal S Front Pharmacol. 2023; 13:1046687.

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Superantigen influence in conjunction with cytokine polymorphism potentiates autoimmunity in systemic lupus erythematosus patients.

Dar S, Janahi E, Haque S, Akhter N, Jawed A, Wahid M Immunol Res. 2015; 64(4):1001-12.

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