Loss of Basal Cell Phenotype with Acquisition of Lung-colonizing Capability in Mouse Mammary Tumors

Overview

Journal Breast Cancer Res Treat

Specialty Oncology

Date 1991 Jan 1

PMID 1710155

Citations 2

Authors

A Tsubura

T Inui

S Morii

S H Dairkee

T Oikawa

A Matsuzawa

Affiliations

Soon will be listed here.

Abstract

A transplantable pregnancy-dependent mouse mammary tumor, TPDMT-4, and its ovarian-dependent (T4-OR26) and autonomous (T4-OI96, T4-OI145, T4-OI165, T4-OI320 and T4-OI320CY) sublines were examined immunohistochemically for the expression of keratin 14 and type IV collagen. T4-OI96, T4-OI145, and T4-OI165, but not T4-OR26, T4-OI320, or T4-OI320CY, formed lung colonies (metastasis) after intravenous injection as a single-cell suspension. Despite the similar morphology of TPDMT-4 and its six sublines, only TPDMT-4 and the nonmetastatic sublines revealed a basal cell phenotype as defined by keratin 14 expression. Staining for type IV collagen was complete at the peripheries of the glandular structures in TPDMT-4 and nonmetastatic sublines but was patchy in the metastatic tumors.

Citing Articles

Multistep mouse mammary tumorigenesis through pre-neoplasia to neoplasia and acquisition of metastatic potential.

Tsubura A, Yoshizawa K, Uehara N, Yuri T, Matsuoka Y Med Mol Morphol. 2007; 40(1):9-17.

PMID: 17384984 DOI: 10.1007/s00795-006-0351-6.

Characterization of mammary plaques in DDD mice congenic for Mtv-2 gene, DDD/1-Mtv-2/Mtv-2.

Matsuzawa A, Kaneko T, Takeda Y, Murakami A, Tsubura A Jpn J Cancer Res. 1993; 84(1):48-54.

PMID: 8383648 PMC: 5919030. DOI: 10.1111/j.1349-7006.1993.tb02783.x.

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