Penile, Urethral, and Seminal Sampling for Diagnosis of Human Papillomavirus Infection in Men

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2006 Nov 10

PMID 17093029

Citations 8

Authors

Lucia Giovannelli

Maria Colomba Migliore

Giuseppina Capra

Maria Pia Caleca

Carmelina Bellavia

Antonio Perino

Enza Viviano

Domenica Matranga

Pietro Ammatuna

Affiliations

Soon will be listed here.

Abstract

Methods that used specimens from three genital sites (penile brushing [PB], urethral brushing [UB], and the retrieval of semen [SE]) from 50 men were examined for human papillomavirus (HPV) DNA detection. The rates of detection by PB, UB, SE, PB and UB, and PB and SE were 88.9%, 50.0%, 33.3%, 100%, and 97.2%, respectively. The use of PB and UB appears to be the most accurate method; as an alternative to UB, the use of SE with PB could be used to improve the rate of HPV DNA detection in men.

Citing Articles

Human Papillomavirus (HPV) Infection and Its Impact on Male Infertility.

Capra G, Notari T, Butta M, Serra N, Rizzo G, Bosco L Life (Basel). 2022; 12(11).

PMID: 36431054 PMC: 9697777. DOI: 10.3390/life12111919.

Potential impact of a nonavalent anti HPV vaccine in Italian men with and without clinical manifestations.

Bosco L, Serra N, Fasciana T, Pistoia D, Vella M, Gregorio L Sci Rep. 2021; 11(1):4096.

PMID: 33603082 PMC: 7892856. DOI: 10.1038/s41598-021-83639-6.

Natural history of human papillomavirus and vaccinations in men: A literature review.

Lieblong B, Montgomery B, Su L, Nakagawa M Health Sci Rep. 2019; 2(5):e118.

PMID: 31139757 PMC: 6529831. DOI: 10.1002/hsr2.118.

Seminal human papillomavirus originates from the body surface and is not a frequent aetiological factor in azoospermia.

Fedder J, Ornskov D, Engvad B, Kristensen T, Lomholt M, Marcussen N Andrologia. 2018; 51(3):e13202.

PMID: 30565706 PMC: 7379244. DOI: 10.1111/and.13202.

The risk of human papillomavirus infection for male fertility abnormality: a meta-analysis.

Xiong Y, Chen Y, Cheng M, He W, Chen Q Asian J Androl. 2018; 20(5):493-497.

PMID: 29623908 PMC: 6116676. DOI: 10.4103/aja.aja_77_17.

References

Hillman R, Ryait B, Botcherby M, Taylor-Robinson D . Changes in HPV infection in patients with anogenital warts and their partners. Genitourin Med. 1993; 69(6):450-6. PMC: 1195150. DOI: 10.1136/sti.69.6.450. View

Martin 3rd R, Rady P, Arany I, Tyring S . Benign Leydig cell tumor of the testis associated with human papillomavirus type 33 presenting with the sign of Leser-Trélat. J Urol. 1993; 150(4):1246-50. DOI: 10.1016/s0022-5347(17)35745-2. View

Astori G, Pipan C, Muffato G, Botta G . Detection of HPV-DNA in semen, urine and urethral samples by dot blot and PCR. New Microbiol. 1995; 18(2):143-9. View

Castellsague X, Ghaffari A, Daniel R, Bosch F, Munoz N, Shah K . Prevalence of penile human papillomavirus DNA in husbands of women with and without cervical neoplasia: a study in Spain and Colombia. J Infect Dis. 1997; 176(2):353-61. DOI: 10.1086/514052. View

Kleter B, van Doorn L, Ter Schegget J, Schrauwen L, van Krimpen K, Burger M . Novel short-fragment PCR assay for highly sensitive broad-spectrum detection of anogenital human papillomaviruses. Am J Pathol. 1998; 153(6):1731-9. PMC: 1866345. DOI: 10.1016/S0002-9440(10)65688-X. View

Golijow C, Perez L, Smith J, Abba M . Human papillomavirus DNA detection and typing in male urine samples from a high-risk population from Argentina. J Virol Methods. 2005; 124(1-2):217-20. DOI: 10.1016/j.jviromet.2004.11.011. View

Nicolau S, Camargo C, Stavale J, Castelo A, Dores G, Lorincz A . Human papillomavirus DNA detection in male sexual partners of women with genital human papillomavirus infection. Urology. 2005; 65(2):251-5. DOI: 10.1016/j.urology.2004.09.031. View

Kjaer S, Munk C, Winther J, Jorgensen H, Meijer C, van den Brule A . Acquisition and persistence of human papillomavirus infection in younger men: a prospective follow-up study among Danish soldiers. Cancer Epidemiol Biomarkers Prev. 2005; 14(6):1528-33. DOI: 10.1158/1055-9965.EPI-04-0754. View

Partridge J, Koutsky L . Genital human papillomavirus infection in men. Lancet Infect Dis. 2005; 6(1):21-31. DOI: 10.1016/S1473-3099(05)70323-6. View

10.

Aguilar L, Lazcano-Ponce E, Vaccarella S, Cruz A, Hernandez P, Smith J . Human papillomavirus in men: comparison of different genital sites. Sex Transm Infect. 2006; 82(1):31-3. PMC: 2563819. DOI: 10.1136/sti.2005.015131. View

11.

Olatunbosun O, Deneer H, Pierson R . Human papillomavirus DNA detection in sperm using polymerase chain reaction. Obstet Gynecol. 2001; 97(3):357-60. DOI: 10.1016/s0029-7844(00)01183-2. View

12.

Levy R, Tardy J, Bourlet T, Cordonier H, Mion F, Lornage J . Transmission risk of hepatitis C virus in assisted reproductive techniques. Hum Reprod. 2000; 15(4):810-6. DOI: 10.1093/humrep/15.4.810. View

13.

Dunne E, Nielson C, Stone K, Markowitz L, Giuliano A . Prevalence of HPV infection among men: A systematic review of the literature. J Infect Dis. 2006; 194(8):1044-57. DOI: 10.1086/507432. View

14.

Lazcano-Ponce E, Herrero R, Munoz N, Hernandez-Avila M, Salmeron J, Leyva A . High prevalence of human papillomavirus infection in Mexican males: comparative study of penile-urethral swabs and urine samples. Sex Transm Dis. 2001; 28(5):277-80. DOI: 10.1097/00007435-200105000-00007. View

15.

Franceschi S, Castellsague X, Dal Maso L, Smith J, Plummer M, Ngelangel C . Prevalence and determinants of human papillomavirus genital infection in men. Br J Cancer. 2002; 86(5):705-11. PMC: 2375316. DOI: 10.1038/sj.bjc.6600194. View

16.

Giovannelli L, Campisi G, Lama A, Giambalvo O, Osborn J, Margiotta V . Human papillomavirus DNA in oral mucosal lesions. J Infect Dis. 2002; 185(6):833-6. DOI: 10.1086/339193. View

17.

Rintala M, Pollanen P, Nikkanen V, Grenman S, Syrjanen S . Human papillomavirus DNA is found in the vas deferens. J Infect Dis. 2002; 185(11):1664-7. DOI: 10.1086/340421. View

18.

Aynaud O, Poveda J, Huynh B, Guillemotonia A, Barrasso R . Frequency of herpes simplex virus, cytomegalovirus and human papillomavirus DNA in semen. Int J STD AIDS. 2002; 13(8):547-50. DOI: 10.1258/095646202760159666. View

19.

Bleeker M, Hogewoning C, van den Brule A, Voorhorst F, van Andel R, Risse E . Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia. J Am Acad Dermatol. 2002; 47(3):351-7. DOI: 10.1067/mjd.2002.122198. View

20.

Baldwin S, Wallace D, Papenfuss M, Abrahamsen M, Vaught L, Kornegay J . Human papillomavirus infection in men attending a sexually transmitted disease clinic. J Infect Dis. 2003; 187(7):1064-70. DOI: 10.1086/368220. View