Thymic Output: Influence Factors and Molecular Mechanism
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Thymus is a primary lymphoid organ, able to generate mature T cells that eventually colonize secondary lymphoid organs, and is therefore essential for peripheral T cell renewal. Recent data showed that normal thymocyte export can be altered by several influence factors including several chemokines, sphingosine1-phosphate (S1P), transcription factors such as Foxj1, Kruppel-like transcription factor 2 (KLF2) and antigen stimulation, etc. In this review, we summarized the recent reports about study strategies, influence factors and possible molecular mechanisms in thymic output.
Decreased Thymic Output Contributes to Immune Defects in Septic Patients.
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PMID: 24757506 PMC: 3995209. DOI: 10.5936/csbj.201403003.
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PMID: 24187562 PMC: 3804360. DOI: 10.1155/2013/282870.