Effects of Bay K 8644 on the Spontaneous Electrical and Mechanical Activities of the Rat Portal Vein

Overview

Journal Naunyn Schmiedebergs Arch Pharmacol

Specialty Pharmacology

Date 1990 Nov 1

PMID 1708854

Authors

K Shimamura

S Sunano

Affiliations

Soon will be listed here.

Abstract

Effects of Bay K 8644 on the spontaneous electrical and mechanical activities of the rat portal vein were studied. Bay K 8644 enhanced contractions in amplitude and duration. Bay K 8644 prolonged the duration of the spontaneous spike potential bursts and increased the number of spike potentials in a burst. These results indicate that the increase in the amplitude and duration of spontaneous contractions of the rat portal vein induced by Bay K 8644 are mediated mainly by the facilitation of the membrane electrical activity.

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