Genetic Epidemiology of Acute Respiratory Distress Syndrome: Implications for Future Prevention and Treatment

Overview

Journal Clin Chest Med

Specialty Pulmonary Medicine

Date 2006 Nov 7

PMID 17085257

Citations 13

Authors

Michelle Ng Gong

Affiliations

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Abstract

The genetic susceptibility to the development of and variable outcomes in acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has become a topic of great interest in the pulmonary and critical care community. Published studies of variable genetic susceptibility to ALI/ARDS already have identified some important candidate genes and potential gene-environment interactions. This article reviews these recent studies, features of the current approach, and implications for future prevention and treatment in ALI. The challenges and potential contributions of genetic epidemiology to the future prevention and treatment in ALI are discussed.

Citing Articles

Personalized medicine using omics approaches in acute respiratory distress syndrome to identify biological phenotypes.

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Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome.

Sapru A, Liu K, Wiemels J, Hansen H, Pawlikowska L, Poon A Crit Care. 2016; 20(1):151.

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Approach to the patient with the acute respiratory distress syndrome.

Janz D, Ware L Clin Chest Med. 2014; 35(4):685-96.

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Identification of novel single nucleotide polymorphisms associated with acute respiratory distress syndrome by exome-seq.

Shortt K, Chaudhary S, Grigoryev D, Heruth D, Venkitachalam L, Zhang L PLoS One. 2014; 9(11):e111953.

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Molecular pathology of emerging coronavirus infections.

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References

Marks J, Marks C, Luce J, Montgomery A, Turner J, Metz C . Plasma tumor necrosis factor in patients with septic shock. Mortality rate, incidence of adult respiratory distress syndrome, and effects of methylprednisolone administration. Am Rev Respir Dis. 1990; 141(1):94-7. DOI: 10.1164/ajrccm/141.1.94. View

Garred P, Strom J, Quist L, Taaning E, Madsen H . Association of mannose-binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis. 2003; 188(9):1394-403. DOI: 10.1086/379044. View

Marshall R, Webb S, Bellingan G, Montgomery H, Chaudhari B, McAnulty R . Angiotensin converting enzyme insertion/deletion polymorphism is associated with susceptibility and outcome in acute respiratory distress syndrome. Am J Respir Crit Care Med. 2002; 166(5):646-50. DOI: 10.1164/rccm.2108086. View

Veletza S, Rogan P, TenHave T, Olowe S, Floros J . Racial differences in allelic distribution at the human pulmonary surfactant protein B gene locus (SP-B). Exp Lung Res. 1996; 22(4):489-94. DOI: 10.3109/01902149609046037. View

Lin Z, Pearson C, Chinchilli V, Pietschmann S, Luo J, Pison U . Polymorphisms of human SP-A, SP-B, and SP-D genes: association of SP-B Thr131Ile with ARDS. Clin Genet. 2000; 58(3):181-91. DOI: 10.1034/j.1399-0004.2000.580305.x. View

Nonas S, Finigan J, Gao L, Garcia J . Functional genomic insights into acute lung injury: role of ventilators and mechanical stress. Proc Am Thorac Soc. 2005; 2(3):188-94. DOI: 10.1513/pats.200501-005AC. View

Wacholder S, Rothman N, Caporaso N . Population stratification in epidemiologic studies of common genetic variants and cancer: quantification of bias. J Natl Cancer Inst. 2000; 92(14):1151-8. DOI: 10.1093/jnci/92.14.1151. View

Suter P, Suter S, Girardin E, Roux-Lombard P, Grau G, Dayer J . High bronchoalveolar levels of tumor necrosis factor and its inhibitors, interleukin-1, interferon, and elastase, in patients with adult respiratory distress syndrome after trauma, shock, or sepsis. Am Rev Respir Dis. 1992; 145(5):1016-22. DOI: 10.1164/ajrccm/145.5.1016. View

Armstrong L, Millar A . Relative production of tumour necrosis factor alpha and interleukin 10 in adult respiratory distress syndrome. Thorax. 1997; 52(5):442-6. PMC: 1758565. DOI: 10.1136/thx.52.5.442. View

10.

Ware L, Conner E, Matthay M . von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med. 2002; 29(12):2325-31. DOI: 10.1097/00003246-200112000-00016. View

11.

Ferguson N, Frutos-Vivar F, Esteban A, Fernandez-Segoviano P, Aramburu J, Najera L . Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions. Crit Care Med. 2005; 33(10):2228-34. DOI: 10.1097/01.ccm.0000181529.08630.49. View

12.

Govan V, Constant D, Hoffman M, Williamson A . The allelic distribution of -308 Tumor Necrosis Factor-alpha gene polymorphism in South African women with cervical cancer and control women. BMC Cancer. 2006; 6:24. PMC: 1397852. DOI: 10.1186/1471-2407-6-24. View

13.

Gallagher P, Lowe G, Fitzgerald T, Bella A, Greene C, McElvaney N . Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax. 2003; 58(2):154-6. PMC: 1746580. DOI: 10.1136/thorax.58.2.154. View

14.

Moss M, Mannino D . Race and gender differences in acute respiratory distress syndrome deaths in the United States: an analysis of multiple-cause mortality data (1979- 1996). Crit Care Med. 2002; 30(8):1679-85. DOI: 10.1097/00003246-200208000-00001. View

15.

Marshall R, Webb S, Hill M, Humphries S, Laurent G . Genetic polymorphisms associated with susceptibility and outcome in ARDS. Chest. 2002; 121(3 Suppl):68S-69S. DOI: 10.1378/chest.121.3_suppl.68s. View

16.

Thickett D, Armstrong L, Millar A . A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med. 2002; 166(10):1332-7. DOI: 10.1164/rccm.2105057. View

17.

Gong M, Thompson B, Williams P, Zhou W, Wang M, Pothier L . Interleukin-10 polymorphism in position -1082 and acute respiratory distress syndrome. Eur Respir J. 2006; 27(4):674-81. PMC: 3090261. DOI: 10.1183/09031936.06.00046405. View

18.

de Boer A , Leufkens H . The interface between pharmacoepidemiology and pharmacogenetics. Eur J Pharmacol. 2001; 410(2-3):121-130. DOI: 10.1016/s0014-2999(00)00810-4. View

19.

Jia S, Li Y, Parodo J, Kapus A, Fan L, Rotstein O . Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis. J Clin Invest. 2004; 113(9):1318-27. PMC: 398427. DOI: 10.1172/JCI19930. View

20.

Floros J, Veletza S, Kotikalapudi P, Krizkova L, Karinch A, Friedman C . Dinucleotide repeats in the human surfactant protein-B gene and respiratory-distress syndrome. Biochem J. 1995; 305 ( Pt 2):583-90. PMC: 1136402. DOI: 10.1042/bj3050583. View