» Articles » PMID: 17083485

The Physical and Chemical Properties of Eumelanin

Overview
Specialty Cell Biology
Date 2006 Nov 7
PMID 17083485
Citations 205
Authors
Affiliations
Soon will be listed here.
Abstract

In this article, we review the current state of knowledge concerning the physical and chemical properties of the eumelanin pigment. We examine properties related to its photoprotective functionality, and draw the crucial link between fundamental molecular structure and observable macroscopic behaviour. Where necessary, we also briefly review certain aspects of the pheomelanin literature to draw relevant comparison. A full understanding of melanin function, and indeed its role in retarding or promoting the disease state, can only be obtained through a full mapping of key structure-property relationships in the main pigment types. We are engaged in such an endeavor for the case of eumelanin.

Citing Articles

Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation.

Ni X, Luo X, Jiang X, Chen W, Bai R Molecules. 2025; 30(4).

PMID: 40005101 PMC: 11858095. DOI: 10.3390/molecules30040788.


An iterative synthesis of poly-substituted indole oligomers reveals a short effective conjugation length in eumelanin model compounds.

Huang H, Kinziabulatova L, Manickoth A, Zhang Y, Barilla M, Blancafort L Chem Sci. 2025; 16(10):4537-4548.

PMID: 39981036 PMC: 11836627. DOI: 10.1039/d4sc08610d.


Design, Synthesis, and Anti-Tyrosinase, Anti-Melanogenic, and Antioxidant Activities of Novel -3-Benzyl-5-Benzylidene-2-Thioxothiazolidin-4-One Analogs.

Park H, Jin Jung H, Soo Park H, Kim H, Park Y, Chun P Molecules. 2025; 30(3).

PMID: 39942621 PMC: 11820736. DOI: 10.3390/molecules30030517.


Melanin in fungi: advances in structure, biosynthesis, regulation, and metabolic engineering.

Qin Y, Xia Y Microb Cell Fact. 2024; 23(1):334.

PMID: 39696244 PMC: 11657710. DOI: 10.1186/s12934-024-02614-8.


New Insights Into The Melanin Structure Of .

Liporagi-Lopes L, Chrissian C, Kacirani A, Camacho E, Stark R, Casadevall A bioRxiv. 2024; .

PMID: 39554014 PMC: 11565999. DOI: 10.1101/2024.11.01.621558.