Effect of Substance P on the Membrane Potential of Coronary Arterial Endothelial Cells in Situ

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1990 Nov 1

PMID 1707586

Citations 2

Authors

J L Beny

Affiliations

Soon will be listed here.

Abstract

The membrane potential of the endothelial cells on a strip of pig coronary artery was recorded. The fluorescent dye lucifer yellow was injected into the recorded cell in order to prove its identity. We show that substance P transiently hyperpolarized these cells. The function of the endothelial cell hyperpolarization could be important for the role played by the endothelium and the kinins in inflammation.

Citing Articles

An evaluation of potassium ions as endothelium-derived hyperpolarizing factor in porcine coronary arteries.

Beny J, Schaad O Br J Pharmacol. 2000; 131(5):965-73.

PMID: 11053218 PMC: 1572415. DOI: 10.1038/sj.bjp.0703658.

Effect of 5-hydroxytryptamine on the membrane potential of endothelial and smooth muscle cells in the pig coronary artery.

Frieden M, Beny J Br J Pharmacol. 1995; 115(1):95-100.

PMID: 7647989 PMC: 1908759. DOI: 10.1111/j.1476-5381.1995.tb16325.x.

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