Mannose-binding Lectin and Maladies of the Bowel and Liver

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2006 Oct 31

PMID 17072973

Citations 9

Authors

Daniel-L Worthley

Peter-G Bardy

David-L Gordon

Charles-G Mullighan

Affiliations

Soon will be listed here.

Abstract

Mannose-binding lectin (MBL) is a pattern-recognition molecule that binds to characteristic carbohydrate motifs present on the surface of many different pathogens. MBL binding stimulates the immune system via the lectin pathway of complement activation. In certain clinical situations, often characterized by pre-existing immune compromise, MBL deficiency increases the risk of infectious and other disease-specific complications. Many of the key pathogenic processes inherent to common gastroenterological diseases, such as infection, immunological damage, and carcinogenesis, have been linked to MBL. This editorial reviews the biology of MBL, outlines key disease associations to document the breadth of influence of MBL, and finally, highlights the relevance of MBL to both gastroenterological health and disease.

Citing Articles

Role of Polymorphisms in Sepsis and Survival: A Pilot Study and In Silico Analysis.

Behairy M, Abdelrahman A, Abdallah H, Ibrahim E, Hashem H, Sayed A Diagnostics (Basel). 2022; 12(2).

PMID: 35204551 PMC: 8871458. DOI: 10.3390/diagnostics12020460.

"Complimenting the Complement": Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma.

Malik A, Thanekar U, Amarachintha S, Mourya R, Nalluri S, Bondoc A Front Oncol. 2021; 10:627701.

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Hypolipidemic Effects of β-Glucans, Mannans, and Fucoidans: Mechanism of Action and Their Prospects for Clinical Application.

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PMID: 32316136 PMC: 7221696. DOI: 10.3390/molecules25081819.

Mannose-Binding Lectin: A Potential Therapeutic Candidate against Infection.

Hammad N, El Badawy N, Ghramh H, Al Kady L Biomed Res Int. 2018; 2018:2813737.

PMID: 29854737 PMC: 5954966. DOI: 10.1155/2018/2813737.

Mannose-Binding Lectin Gene Polymorphism and Its Association with Susceptibility to Recurrent Vulvovaginal Candidiasis.

Hammad N, El Badawy N, Nasr A, Ghramh H, Al Kady L Biomed Res Int. 2018; 2018:7648152.

PMID: 29850562 PMC: 5904809. DOI: 10.1155/2018/7648152.

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