HIV Evolution and Escape

Overview

Journal Trans Am Clin Climatol Assoc

Specialty Rehabilitation Medicine

Date 2006 Oct 25

PMID 17060974

Citations 18

Authors

Douglas D Richman

Susan J Little

Davey M Smith

Terri Wrin

Christos Petropoulos

Joseph K Wong

Affiliations

Soon will be listed here.

Abstract

Human immunodeficiency virus (HIV) exemplifies the principles of Darwinian evolution with a telescoped chronology. Because of its high mutation rate and remarkably high rates of replication, evolution can be appreciated over periods of days in contrast to the durations conceived of by Darwin. Certain selective pressures that drive the evolution of HIV include chemotherapy, anatomic compartmentalization and the immune response. Examples of these selective forces on HIV evolution are described.

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