Risk of Recurrence in a Long-term Follow-up After Surgery in 417 Patients with Hepatitis B- or Hepatitis C-related Hepatocellular Carcinoma

Overview

Journal Ann Surg

Specialty General Surgery

Date 2006 Oct 25

PMID 17060771

Citations 53

Authors

Yo Sasaki

Terumasa Yamada

Hideo Tanaka

Hiroaki Ohigashi

Hidetoshi Eguchi

Masahiko Yano

Osamu Ishikawa

Shingi Imaoka

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study is to clarify the difference of risk of recurrence after hepatic resection between patients with hepatitis B- and hepatitis C-related hepatocellular carcinoma (HCC).

Summary And Background Data: HCC is a highly recurrent carcinoma. However, consensus has not yet been reached about the relationship between hepatitis virus types and risk of recurrence in a long-term follow-up for HCC patients who underwent hepatic resection.

Patients And Methods: From the beginning of January 1990 to the end of December 1999, of 469 HCC patients who underwent curative hepatic resection, 66 (14%) patients with positive hepatitis B virus surface antigen (HBs-Ag) and negative hepatitis C virus antibody (HCV-Ab) were regarded to have B-type hepatitis (HB)-related HCC (HB-HCC) and 351 (75%) with negative HBs-Ag and positive HCV-Ab were regarded to have C-type hepatitis (HC)-related HCC (HC-HCC). A clinical follow-up was performed to assess the existence of recurrence with the median follow-up periods of 11.0 and 10.1 years for HB- and HC-HCC patients, respectively.

Results: The 3-, 5-, and 10-year disease-free survival (DFS) rates of HC-HCC (40%, 24%, and 12%, respectively) were significantly shorter than those of HB-HCC (57%, 54%, and 28%, respectively) (P = 0.0001). In multivariate Cox proportional hazard analysis, viral type, TNM stage, surgical margin, and Edmondson's grade were significantly associated with risk of recurrence. The risk of recurrence from the initial HCC increased to 1.93 times (95% confidence interval, 1.27-2.93) greater in HC-HCC patients than in HB-HCC patients.

Conclusion: Hepatitis viral type is an independent factor for recurrence of HCC in a long-term clinical follow-up. This finding suggests that we may need a different strategy to control postoperative recurrence by the viral types in HCC patients.

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References

EDMONDSON H, STEINER P . Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 1954; 7(3):462-503. DOI: 10.1002/1097-0142(195405)7:3<462::aid-cncr2820070308>3.0.co;2-e. View

Brechot C, Pourcel C, Louise A, Rain B, Tiollais P . Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma. Nature. 1980; 286(5772):533-5. DOI: 10.1038/286533a0. View

Ikai I, Itai Y, Okita K, Omata M, Kojiro M, Kobayashi K . Report of the 15th follow-up survey of primary liver cancer. Hepatol Res. 2004; 28(1):21-29. DOI: 10.1016/j.hepres.2003.08.002. View

Sakon M, Umeshita K, Nagano H, Eguchi H, Kishimoto S, Miyamoto A . Clinical significance of hepatic resection in hepatocellular carcinoma: analysis by disease-free survival curves. Arch Surg. 2000; 135(12):1456-9. DOI: 10.1001/archsurg.135.12.1456. View

Bruix J, Barrera J, Calvet X, Ercilla G, Costa J, Sanchez-Tapias J . Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet. 1989; 2(8670):1004-6. DOI: 10.1016/s0140-6736(89)91015-5. View

Chen M, Jeng L, Lee W, Chen T . Surgical results in patients with dual hepatitis B- and C-related hepatocellular carcinoma compared with hepatitis B- or C-related hepatocellular carcinoma. Surgery. 1998; 123(5):554-9. DOI: 10.1067/msy.1998.87237. View

Shafritz D, Kew M . Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas. Hepatology. 1981; 1(1):1-8. DOI: 10.1002/hep.1840010102. View

Kim C, Koike K, Saito I, Miyamura T, Jay G . HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature. 1991; 351(6324):317-20. DOI: 10.1038/351317a0. View

Kuo G, Choo Q, Alter H, Gitnick G, Redeker A, Purcell R . An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science. 1989; 244(4902):362-4. DOI: 10.1126/science.2496467. View

10.

Miyagawa S, Kawasaki S, Makuuchi M . Comparison of the characteristics of hepatocellular carcinoma between hepatitis B and C viral infection: tumor multicentricity in cirrhotic liver with hepatitis C. Hepatology. 1996; 24(2):307-10. DOI: 10.1053/jhep.1996.v24.pm0008690397. View

11.

Chen M, Jeng L, Lee W . Surgical results in patients with hepatitis virus-related hepatocellular carcinoma in Taiwan. World J Surg. 2002; 26(6):742-7. DOI: 10.1007/s00268-002-6143-9. View

12.

Henderson J, Sherman M, Tavill A, Abecassis M, Chejfec G, Gramlich T . AHPBA/AJCC consensus conference on staging of hepatocellular carcinoma: consensus statement. HPB (Oxford). 2008; 5(4):243-50. PMC: 2020604. DOI: 10.1080/13651820310015833. View

13.

SZMUNESS W . Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association. Prog Med Virol. 1978; 24:40-69. View

14.

Sasaki Y, Imaoka S, Masutani S, Ohashi I, Ishikawa O, Koyama H . Influence of coexisting cirrhosis on long-term prognosis after surgery in patients with hepatocellular carcinoma. Surgery. 1992; 112(3):515-21. View

15.

Choo Q, Kuo G, Weiner A, Overby L, Bradley D, Houghton M . Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989; 244(4902):359-62. DOI: 10.1126/science.2523562. View

16.

Okuda K . Hepatocellular carcinoma: recent progress. Hepatology. 1992; 15(5):948-63. DOI: 10.1002/hep.1840150532. View

17.

Kubo S, Nishiguchi S, Hirohashi K, Tanaka H, Shuto T, Yamazaki O . Effects of long-term postoperative interferon-alpha therapy on intrahepatic recurrence after resection of hepatitis C virus-related hepatocellular carcinoma. A randomized, controlled trial. Ann Intern Med. 2001; 134(10):963-7. DOI: 10.7326/0003-4819-134-10-200105150-00010. View

18.

Yamanaka N, Tanaka T, Tanaka W, Yamanaka J, Yasui C, Kuroda N . Correlation of hepatitis virus serologic status with clinicopathologic features in patients undergoing hepatectomy for hepatocellular carcinoma. Cancer. 1997; 79(8):1509-15. DOI: 10.1002/(sici)1097-0142(19970415)79:8<1509::aid-cncr10>3.0.co;2-1. View

19.

Takano S, Yokosuka O, Imazeki F, Tagawa M, Omata M . Incidence of hepatocellular carcinoma in chronic hepatitis B and C: a prospective study of 251 patients. Hepatology. 1995; 21(3):650-5. View

20.

Pugh R, Murray-Lyon I, Dawson J, Pietroni M, Williams R . Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973; 60(8):646-9. DOI: 10.1002/bjs.1800600817. View