Cocaine Increases 5-HT1B MRNA in Rat Nucleus Accumbens Shell Neurons

Overview

Journal Neuropharmacology

Specialties Neurology
Pharmacology

Date 2006 Oct 25

PMID 17059838

Citations 21

Authors

B J Hoplight

E S Vincow

J F Neumaier

Affiliations

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Abstract

Serotonin 5-HT(1B) receptors modulate behavioral responses to cocaine, but the effects of cocaine on endogenous 5-HT(1B) receptor expression are not known. Therefore, we examined the effect of binge cocaine administration on 5-HT1B mRNA expression in rat brain. We found that chronic, but not acute, binge cocaine exposure increased 5-HT(1B) mRNA by approximately 80% in nucleus accumbens shell and dorsal striatum. Surprisingly, 5-HT(1B) mRNA was increased in nucleus accumbens shell after chronic vehicle treatment as well, but this effect was driven by animals that were housed with cocaine-treated animals. Thus, 5-HT(1B) mRNA is upregulated by repeated exposure to cocaine and perhaps by social stress as well; both of these factors are relevant to the risk for relapse in cocaine addiction.

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