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Resistant Microascus Cirrosus Pneumonia Can Be Treated with a Combination of Surgery, Multiple Anti-fungal Agents and a Growth Factor

Overview
Journal Mycopathologia
Specialties Microbiology
Pharmacology
Date 2006 Oct 14
PMID 17039277
Citations 10
Authors
Celalettin Ustun
Gerwin Huls
Marc Stewart
Kieren A Marr
Affiliations
Soon will be listed here.
Abstract

A 49-year old male with acute myelogenous leukemia relapsed eight years post allogeneic bone marrow transplantation. The patient received induction chemotherapy causing prolonged neutropenia. The patient developed pneumonia for which empirical antibacterial and antifungal therapy were started. The patient underwent a video-assisted thorocascopy with near complete resection of the lesion because of poor response to treatment. Microascus cirrosus was identified in the tissue. In vitro susceptibility test to different antifungal agents showed M. cirrosus was very resistant. The patient is undergoing second allogeneic transplant with improved pneumonia resulting from a combination of treatment for fungal infection, which included surgery, antifungal agents, and granulocyte-colony stimulating factor. The Microascus genus rarely causes invasive fungal infection in humans and can be very difficult to treat because of the resistance to available antifungal agents.

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