Low-level Laser Therapy Can Reduce Lipopolysaccharide-induced Contractile Force Dysfunction and TNF-alpha Levels in Rat Diaphragm Muscle

Overview

Journal Lasers Med Sci

Publisher Springer

Date 2006 Oct 13

PMID 17033742

Citations 8

Authors

F Aimbire

R A B Lopes-Martins

H C Castro-Faria-Neto

R Albertini

M C Chavantes

M T T Pacheco

P S L M Leonardo

V V Iversen

J M Bjordal

Affiliations

Soon will be listed here.

Abstract

Our objective was to investigate if low-level laser therapy (LLLT) could improve respiratory function and inhibit tumor necrosis factor (TNF-alpha) release into the diaphragm muscle of rats after an intravenous injection of lipopolysaccharide (LPS) (5 mg/kg). We randomly divided Wistar rats in a control group without LPS injection, and LPS groups receiving either (a) no therapy, (b) four sessions in 24 h with diode Ga-AsI-Al laser of 650 nm and a total dose of 5.2 J/cm2, or (c) an intravenous injection (1.25 mg/kg) of the TNF-alpha inhibitor chlorpromazine (CPZ). LPS injection reduced maximal force by electrical stimulation of diaphragm muscle from 24.15+/-0.87 N in controls, but the addition of LLLT partly inhibited this reduction (LPS only: 15.01+/-1.1 N vs LPS+LLLT: 18.84+/-0.73 N, P<0.05). In addition, this dose of LLLT and CPZ significantly (P<0.05 and P<0.01, respectively) reduced TNF-alpha concentrations in diaphragm muscle when compared to the untreated control group.

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