Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK1) Receptor Antagonist

Overview

Journal Science

Specialty Science

Date 1991 Jan 25

PMID 1703324

Citations 24

Authors

S McLean

A H Ganong

T F Seeger

D K Bryce

K G Pratt

L S Reynolds

C J Siok

J A Lowe 3rd

J Heym

Affiliations

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Abstract

CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK1 receptor. The compound binds to a single population of sites in guinea pig brain and potently inhibits substance P-induced excitation of locus ceruleus neurons. CP-96,345 should be a useful tool for studying the action of substance P in the central nervous system.

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