Quantification of Distal Antral Contractile Motility in Healthy Human Stomach with Magnetic Resonance Imaging
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Purpose: To quantify healthy postprandial: 1) propagation, periodicity, geometry, and percentage occlusion by distal antral contraction waves (ACWs); and 2) changes in ACW activity in relationship to gastric emptying (GE).
Materials And Methods: Using 1.5-T MR scanner, nine healthy fasted volunteers were examined in the right decubitus position after ingestion of 500 mL of 10% glucose (200 kcal) with 500 microM Gd-DOTA. Total gastric (TGV) and meal volumes (MV) were assessed every five minutes for 90 minutes, in and interspersed with dynamic scan sequences (duration: 2.78 minutes) providing detailed images of distal ACWs.
Results: TGV increased by 738+/-38 mL after ingestion (t0), subsequently decreasing in parallel to GE. The mean GE rate and half-emptying time were 24+/-3 mL/5 minutes and 71+/-6 minutes, respectively. Accompanying ACWs reached a periodicity of 23+/-2 seconds at t35 and propagated at an unvarying speed of 0.27+/-0.01 cm/second. Their amplitude of 0.70+/-0.08 cm was constant, but the width decreased along the antral wall by 6+/-2%/cm (P=0.003). ACWs were nonocclusive (percentage occlusion 58.1+/-5.9%, t0 at the pylorus) with a reduction in occlusion away from the pylorus (P<0.001). No propagation and geometry characteristics of ACWs correlated with the changes of MV (mL/5 minutes; R2<0.05).
Conclusion: Our results indicate that ACWs are not imperative for emptying of liquids. This study provides a detailed quantitative reference for MRI inquiries into pharmacologically- and pathologically-altered gastric motility.
Hosseini S, Avci R, Paskaranandavadivel N, Suresh V, Cheng L IEEE Open J Eng Med Biol. 2023; 4:38-44.
PMID: 37138590 PMC: 10151011. DOI: 10.1109/OJEMB.2023.3261224.
Driever T, Hulshof M, Bel A, Sonke J, van der Horst A J Appl Clin Med Phys. 2022; 24(4):e13864.
PMID: 36565168 PMC: 10113698. DOI: 10.1002/acm2.13864.
Non-uniform gastric wall kinematics revealed by 4D Cine magnetic resonance imaging in humans.
Sclocco R, Nguyen C, Staley R, Fisher H, Mendez A, Velez C Neurogastroenterol Motil. 2021; 33(8):e14146.
PMID: 33797166 PMC: 10315015. DOI: 10.1111/nmo.14146.
Heissam K, Abrehart N, Hoad C, Wright J, Menys A, Murray K PLoS One. 2020; 15(11):e0241441.
PMID: 33175860 PMC: 7657519. DOI: 10.1371/journal.pone.0241441.
Ishida S, Miyagawa T, OGrady G, Cheng L, Imai Y J R Soc Interface. 2019; 16(157):20190266.
PMID: 31387481 PMC: 6731493. DOI: 10.1098/rsif.2019.0266.