Human Neutrophil Peptides 1, 2 and 3 Are Biochemical Markers for Metastatic Colorectal Cancer

Overview

Journal Eur J Cancer

Specialty Oncology

Date 2006 Oct 4

PMID 17015013

Citations 22

Authors

Jakob Albrethsen

Christian H Moller

Jesper Olsen

Hans Raskov

Steen Gammeltoft

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) patients have increased levels of human neutrophil peptides 1-3 (HNP1-3) in tumour tissue and plasma. The aim is to study whether the amount of HNP1-3 in tumour and plasma from CRC patients correlate with Dukes' stages A-D. The amount of HNP1-3 in tumour tissue, normal colonic mucosa, and plasma was determined with mass spectrometry. Plasma levels of HNP1-3 were determined with enzyme-linked immuno-sorbent assay (ELISA). The amount of HNP1-3 determined with mass spectrometry was increased in tumours compared to normal colonic tissue in CRC patients in Dukes' stage A-D, whereas HNP1-3 in plasma was only elevated in Dukes' stage D compared to healthy individuals. HNP1-3 plasma concentration determined with ELISA was increased in Dukes' stages C and D, but not in A and B. It is concluded that HNP1-3 is a potential marker for prognostic assessment, surveillance of patients, and monitoring chemotherapy in CRC patients with advanced disease.

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