Activity of Matrix Metalloproteinase-2 (MMP-2) in Canine Oronasal Tumors

Overview

Journal Res Vet Sci

Specialty Veterinary Medicine

Date 2006 Oct 3

PMID 17011604

Citations 5

Authors

Munekazu Nakaichi

Toshi Yunuki

Masaru Okuda

Satoshi Une

Yasuho Taura

Affiliations

Soon will be listed here.

Abstract

Activity of matrix metalloprotease-2 (MMP-2) and the expression of its related molecules were examined in spontaneous canine oronasal tumors. Tissue samples from melanoma and squamous cell carcinoma possessed higher MMP-2 activity, as shown in gelatin zymography, in comparison with acanthomatous epulis and nasal adenocarcinoma. Regional lymph node invasion and distant metastases were more frequently observed in the MMP-2 positive cases. There were no significant differences by RT-PCR examination in the expression of the genes encoding MMP-2, MT1-MMP and TIMP-2 among the tumor histological types. However, the MMP-2/TIMP-2 ratio showed a significantly higher level of the genes in the malignant oral melanoma and squamous cell carcinoma. The MMP-2/TIMP-2 ratio was also positively correlated with MMP-2 activity in gelatin zymography. These results indicate that the MMP-2/TIMP-2 ratio may be of value in evaluating the prognosis in canine oronasal cavity tumors.

Citing Articles

An Update on Molecular Pathways Regulating Vasculogenic Mimicry in Human Osteosarcoma and Their Role in Canine Oncology.

Massimini M, Romanucci M, De Maria R, Della Salda L Front Vet Sci. 2021; 8:722432.

PMID: 34631854 PMC: 8494780. DOI: 10.3389/fvets.2021.722432.

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas.

Nishiya A, Nagamine M, da Fonseca I, Miraldo A, Scattone N, Luiz Guerra J Toxins (Basel). 2020; 12(3).

PMID: 32121654 PMC: 7150776. DOI: 10.3390/toxins12030157.

Evaluation of chemotherapy with nanosomal paclitaxel and gene therapy expressing apoptosis-inducing proteins in the management of spontaneous canine mammary neoplasm.

Divya M, Maiti S, Sangeetha P, Shivaraju S, Kumar N, Tiwari A J Stem Cells Regen Med. 2020; 15(2):24-34.

PMID: 31983855 PMC: 6971383.

Diagnostic procedures for improving of the KIT (CD117) expressed allele burden for the liver metastases from uterus mast cell tumors: prognostic value of the metastatic pattern and tumor biology.

Hosseini E, Pedram B, Bahrami A, Touni S, Malayeri H, Mokarizadeh A Tumour Biol. 2014; 36(2):929-37.

PMID: 25315185 DOI: 10.1007/s13277-014-2666-6.

Matrix metalloproteinases and their inhibitors in canine mammary tumors.

Aresu L, Giantin M, Morello E, Vascellari M, Castagnaro M, Lopparelli R BMC Vet Res. 2011; 7:33.

PMID: 21726449 PMC: 3141405. DOI: 10.1186/1746-6148-7-33.