Three Different MRNAs Encoding Human Granulocyte Colony-stimulating Factor Receptor

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1990 Nov 1

PMID 1701053

Citations 53

Authors

R Fukunaga

Y Seto

S Mizushima

S Nagata

Affiliations

Soon will be listed here.

Abstract

Three cDNAs for the human granulocyte colony-stimulating factor (G-CSF) receptor were isolated from the cDNA libraries of human U937 leukemia cells and placenta by using a murine G-CSF receptor cDNA as the probe. The human G-CSF receptor containing 813 amino acids had a marked homology (62.5%) with its murine counterpart and consisted of extracellular, transmembrane, and cytoplasmic domains. The WSXWS motif found in members of the newly identified growth factor receptor family was also present in the extracellular domain of the human G-CSF receptor. Expression of the cloned cDNA in monkey COS cells gave rise to a protein that could specifically bind G-CSF with a high affinity (Kd, 550 pM). Two other classes of the human G-CSF receptor were also identified, one of which had a deletion of the transmembrane domain and seemed to encode a secreted, soluble receptor. The third class of the G-CSF receptor contained a 27-amino acid insertion in the cytoplasmic domain and was highly expressed in placenta.

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References

Fukunaga R, Matsuyama M, Okamura H, Nagata K, Nagata S, SOKAWA Y . Undermethylation of interferon-gamma gene in human T cell lines and normal T lymphocytes. Nucleic Acids Res. 1986; 14(11):4421-36. PMC: 311456. DOI: 10.1093/nar/14.11.4421. View

Watari K, Asano S, Shirafuji N, Kodo H, Ozawa K, Takaku F . Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay. Blood. 1989; 73(1):117-22. View

Bazan J . A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain. Biochem Biophys Res Commun. 1989; 164(2):788-95. DOI: 10.1016/0006-291x(89)91528-3. View

Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T . Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. Cell. 1989; 58(3):573-81. DOI: 10.1016/0092-8674(89)90438-8. View

Mosley B, Beckmann M, March C, Idzerda R, Gimpel S, Vandenbos T . The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms. Cell. 1989; 59(2):335-48. DOI: 10.1016/0092-8674(89)90295-x. View

Nicola N, Peterson L . Identification of distinct receptors for two hemopoietic growth factors (granulocyte colony-stimulating factor and multipotential colony-stimulating factor) by chemical cross-linking. J Biol Chem. 1986; 261(26):12384-9. View

Gearing D, King J, Gough N, Nicola N . Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J. 1989; 8(12):3667-76. PMC: 402049. DOI: 10.1002/j.1460-2075.1989.tb08541.x. View

Nicola N . Hemopoietic cell growth factors and their receptors. Annu Rev Biochem. 1989; 58:45-77. DOI: 10.1146/annurev.bi.58.070189.000401. View

Logan P, Shellard J, Buskard N, LEVY J . CAMAL: evidence for an inhibitory role in normal granulopoiesis. Exp Hematol. 1989; 17(11):1072-6. View

10.

Morstyn G, Lieschke G, Sheridan W, Layton J, Cebon J . Pharmacology of the colony-stimulating factors. Trends Pharmacol Sci. 1989; 10(4):154-9. DOI: 10.1016/0165-6147(89)90168-5. View

11.

Santoli D, Yang Y, Clark S, Kreider B, Caracciolo D, Rovera G . Synergistic and antagonistic effects of recombinant human interleukin (IL) 3, IL-1 alpha, granulocyte and macrophage colony-stimulating factors (G-CSF and M-CSF) on the growth of GM-CSF-dependent leukemic cell lines. J Immunol. 1987; 139(10):3348-54. View

12.

Athanassakis I, Bleackley R, Paetkau V, Guilbert L, Barr P, Wegmann T . The immunostimulatory effect of T cells and T cell lymphokines on murine fetally derived placental cells. J Immunol. 1987; 138(1):37-44. View

13.

Leiderman I, Greenberg M, Adelsberg B, Siegal F . A glycoprotein inhibitor of in vitro granulopoiesis associated with AIDS. Blood. 1987; 70(5):1267-72. View

14.

Mizushima S, Nagata S . pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 1990; 18(17):5322. PMC: 332193. DOI: 10.1093/nar/18.17.5322. View

15.

Goodwin R, Friend D, Ziegler S, Jerzy R, Falk B, Gimpel S . Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell. 1990; 60(6):941-51. DOI: 10.1016/0092-8674(90)90342-c. View

16.

Fukunaga R, Nagata S . Purification and characterization of the receptor for murine granulocyte colony-stimulating factor. J Biol Chem. 1990; 265(23):14008-15. View

17.

Avalos B, Gasson J, Hedvat C, Quan S, BALDWIN G, Weisbart R . Human granulocyte colony-stimulating factor: biologic activities and receptor characterization on hematopoietic cells and small cell lung cancer cell lines. Blood. 1990; 75(4):851-7. View

18.

Fukunaga R, Seto Y, Nagata S . Expression cloning of a receptor for murine granulocyte colony-stimulating factor. Cell. 1990; 61(2):341-50. DOI: 10.1016/0092-8674(90)90814-u. View

19.

Nicola N, Metcalf D . Binding of the differentiation-inducer, granulocyte-colony-stimulating factor, to responsive but not unresponsive leukemic cell lines. Proc Natl Acad Sci U S A. 1984; 81(12):3765-9. PMC: 345300. DOI: 10.1073/pnas.81.12.3765. View

20.

Nicola N, Metcalf D, Johnson G, Burgess A . Separation of functionally distinct human granulocyte-macrophage colony-stimulating factors. Blood. 1979; 54(3):614-27. View