Is Measurement of IgM and IgA Rheumatoid Factors (RF) in Juvenile Rheumatoid Arthritis Clinically Useful?

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 2006 Sep 30

PMID 17009016

Citations 3

Authors

Rosa A Ferreira

Carlos H M Silva

Deise A O Silva

Monica C Sopelete

Maria H B Kiss

Jose R Mineo

Virginia P L Ferriani

Affiliations

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Abstract

The prevalence and clinical relevance of IgM and IgA RF detected by ELISA were studied in 91 patients with juvenile rheumatoid arthritis (JRA) and 45 healthy children. IgM and IgA RF were detected, respectively, in 33 and 44% of the patients, compared to 6.7 and 15.6% of the healthy children (p = 0.001 and 0.0006, respectively). The frequency of IgM RF was significantly higher in patients with polyarticular (52%) as compared to systemic onset JRA (21%; p = 0.04). Five out of ninety-one patients and none of the control group were IgM RF positive by the latex test. High levels of IgM RF were detected more frequently in patients with active disease (p = 0.01) and positive latex agglutination test (p < 0.001) and had a marginally significant association with severe radiological deformities (p = 0.05). The presence of IgA RF was associated with active disease in polyarticular onset JRA children (p = 0.04). In conclusion, high levels of IgM RF and the detection of IgA RF can be useful in assessing clinical activity in a subset of patients with JRA.

Citing Articles

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Review of biomarkers in systemic juvenile idiopathic arthritis: helpful tools or just playing tricks?.

Gohar F, Kessel C, Lavric M, Holzinger D, Foell D Arthritis Res Ther. 2016; 18:163.

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Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology.

Syed R, Gilliam B, Moore T Curr Rheumatol Rep. 2008; 10(2):156-63.

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